{"id":"W2805763177","doi":"10.1101/338673","title":"TACAN is an essential component of the mechanosensitive ion channel responsible for pain sensing","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Louise and Alan Edwards Foundation; Agence Nationale de la Recherche; Universities Space Research Association","keywords":"Mechanosensitive channels; Mechanotransduction; Ion channel; Nociceptor; PIEZO1; Neuroscience; Mechanosensation; Nociception; Cell biology; Biophysics; Materials science; Chemistry; Medicine; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403841,0.00028656,0.0001739802,0.0002535651,0.0002563345,0.0004036131,0.0002317715,0.0004971192,0.001660029],"category_scores_gemma":[0.0002188194,0.00008507162,0.0001626636,0.0002124836,0.0002136986,0.0002415021,0.0002988552,0.0005084305,0.0007196684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711306,"about_ca_system_score_gemma":0.0002246531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003177156,"about_ca_topic_score_gemma":0.0001445425,"domain_scores_codex":[0.9999067,0.00001405987,0.000009878459,0.00001957825,0.00003343127,0.00001642742],"domain_scores_gemma":[0.9999033,0.0000109492,0.0000264998,0.000009591698,0.00002136633,0.00002827315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836051,0.00002997623,0.001102355,0.0001112338,0.00001403195,0.0006588211,0.000033305,0.0001446811,0.9844364,0.001524851,0.0009054577,0.01085515],"study_design_scores_gemma":[0.00006476632,0.0002386357,0.03761566,0.00005199293,0.00005369803,0.007296368,0.00007050702,0.004532356,0.8975354,0.002761179,0.04975412,0.00002530547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9435052,0.0148674,0.02595909,0.001983421,0.0005514173,0.00008138464,0.001774822,0.0005832587,0.01069393],"genre_scores_gemma":[0.9795466,0.001949729,0.008045443,0.0002700893,0.00008676719,0.00002432965,0.002008615,0.00002508977,0.00804326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660029,"threshold_uncertainty_score":0.005553305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02379202901219011,"score_gpt":0.2511812906639018,"score_spread":0.2273892616517117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}