{"id":"W2805787161","doi":"10.1212/wnl.90.15_supplement.p6.375","title":"Durable Reduction in MRI Disease Activity and Slowing of Brain Volume Loss in Alemtuzumab-Treated Patients With Active RRMS: 7-Year Follow-up of CARE-MS I Patients (TOPAZ Study) (P6.375)","year":2018,"lang":"en","type":"article","venue":"Neurology","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada); Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"","keywords":"Alemtuzumab; Medicine; Topaz; Multiple sclerosis; Internal medicine; Psychiatry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009158458,0.0004447836,0.000713898,0.0003184385,0.0003625683,0.0007705813,0.0005351757,0.000562434,0.0007054574],"category_scores_gemma":[0.001143772,0.0001635966,0.0005628858,0.0004264343,0.0002490216,0.000626336,0.0003598092,0.0006787828,0.0002246467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004741435,"about_ca_system_score_gemma":0.0004844818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00277476,"about_ca_topic_score_gemma":0.00439711,"domain_scores_codex":[0.9997092,0.00007714896,0.00002487628,0.0000623069,0.00006399272,0.00006241865],"domain_scores_gemma":[0.9992545,0.00007176434,0.0002916779,0.00004845396,0.00008632145,0.0002470988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03291498,0.002313269,0.9146689,0.000178503,0.001622721,0.0002594139,0.0002475361,0.0004525791,0.005051485,0.00006454551,0.001595796,0.04063029],"study_design_scores_gemma":[0.001850348,0.01197243,0.9833836,0.00001936042,0.0006719623,0.0002986046,0.00008710832,0.0003437411,0.0006432766,0.0000538716,0.000660372,0.00001528591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986005,0.0006232705,0.00004201833,0.00004568308,0.000008143147,0.00003438157,0.0003824762,0.000005624001,0.0002578741],"genre_scores_gemma":[0.9979137,0.0002366141,0.0001530165,0.00009147767,0.00003448256,0.00003424059,0.001318255,0.000002382875,0.0002158256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277476,"threshold_uncertainty_score":0.005517244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005627769630637258,"score_gpt":0.2327776323758857,"score_spread":0.2271498627452484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}