{"id":"W2805831701","doi":"10.4049/immunohorizons.1800027","title":"Inflammatory Bowel Disease Susceptibility Gene <i>C1ORF106</i> Regulates Intestinal Epithelial Permeability","year":2018,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Genentech","keywords":"Intestinal permeability; Proinflammatory cytokine; Inflammatory bowel disease; Tight junction; Epithelium; Intestinal epithelium; Tumor necrosis factor alpha; Inflammation; Immunology; Diarrhea; Cell biology; Biology; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007027719,0.0004649519,0.0005522445,0.0001478597,0.0004278828,0.00003623261,0.0003243256,0.0001911593,0.0003803363],"category_scores_gemma":[0.001425479,0.000412506,0.0002795777,0.0002663298,0.002168313,0.0002005778,0.000367906,0.0006462374,0.0006377028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135083,"about_ca_system_score_gemma":0.0003185606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008238404,"about_ca_topic_score_gemma":0.00008804597,"domain_scores_codex":[0.9968541,0.0002460454,0.0007736986,0.0008621257,0.0003972004,0.0008668717],"domain_scores_gemma":[0.9968664,0.0001479142,0.0001756595,0.001516907,0.0007981028,0.0004949931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002276432,0.0004780738,0.8574149,0.00008557363,0.0003805253,0.0001115478,0.0005324322,0.00000125332,0.1355937,0.00005402887,0.001257399,0.001814083],"study_design_scores_gemma":[0.001947819,0.001529134,0.9776011,0.0001374501,0.0003696929,0.0001356126,0.0001086381,0.0000926018,0.0147426,0.0003738301,0.002668785,0.0002928145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937478,0.0003831297,0.0002028636,0.002595009,0.001099717,0.000735188,0.00009758485,0.0004339117,0.0007047445],"genre_scores_gemma":[0.9965876,0.00005917372,0.001005401,0.0005402541,0.001036199,0.00008125535,0.00007509195,0.00006143867,0.0005536104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1208511,"threshold_uncertainty_score":0.9998327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236532175783478,"score_gpt":0.259598093702826,"score_spread":0.2472327719449913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}