{"id":"W2805898508","doi":"10.1038/s41598-018-27225-3","title":"Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nutrition Society; University of Ottawa; Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Bacteriocin; Pediococcus acidilactici; Antimicrobial; Listeria monocytogenes; Clostridium perfringens; Chemistry; Circular dichroism; Peptide; Listeria; Biochemistry; Microbiology; Combinatorial chemistry; Bacteria; Biology; Lactic acid; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009124098,0.000166123,0.0001160451,0.0001382878,0.00008659877,0.0001682849,0.0001535675,0.0001276022,0.0008393984],"category_scores_gemma":[0.0002022964,0.00006543437,0.0001009039,0.0002250296,0.000118152,0.0001355478,0.0001008723,0.0003370845,0.0001452832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406607,"about_ca_system_score_gemma":0.0001425397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004354852,"about_ca_topic_score_gemma":0.0002582523,"domain_scores_codex":[0.999945,0.00001227141,0.000004989478,0.000009836186,0.00001508383,0.00001274164],"domain_scores_gemma":[0.9999352,0.00001267727,0.00001711423,0.000006474436,0.00001125831,0.00001735447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002567198,0.00007405739,0.0001279859,0.00004555717,0.000005632128,0.00008064016,0.000017744,0.0007160085,0.9946409,0.0000982586,0.00003000181,0.003906345],"study_design_scores_gemma":[0.00004236005,0.0009103306,0.00142315,0.000004230319,0.00001346671,0.0001879754,0.00001902392,0.001170662,0.9938853,0.00004749338,0.002288802,0.000007046118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952248,0.0009859707,0.002220441,0.00005297821,0.00001337191,0.00003809608,0.0002686971,0.00001286693,0.001182606],"genre_scores_gemma":[0.9946473,0.0008049139,0.002923545,0.0000343633,0.000006156836,0.00002334004,0.0006095254,0.000007201119,0.0009436283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008393984,"threshold_uncertainty_score":0.002808094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085571769018107,"score_gpt":0.2078061314555884,"score_spread":0.1969504137654073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}