{"id":"W2805898508","doi":"10.1038/s41598-018-27225-3","title":"Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nutrition Society; University of Ottawa; Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Bacteriocin; Pediococcus acidilactici; Antimicrobial; Listeria monocytogenes; Clostridium perfringens; Chemistry; Circular dichroism; Peptide; Listeria; Biochemistry; Microbiology; Combinatorial chemistry; Bacteria; Biology; Lactic acid; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005638064,0.00008244935,0.000170737,0.00003352786,0.0003952311,0.0001453889,0.0001009036,0.000058008,0.0001708735],"category_scores_gemma":[0.00005889378,0.00002857611,0.00008294208,0.0006436291,0.0006167422,0.0001134906,0.0001315906,0.00005216539,0.000001128065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008861197,"about_ca_system_score_gemma":0.00001663529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001214077,"about_ca_topic_score_gemma":0.0005288678,"domain_scores_codex":[0.9990984,0.00004885194,0.0002241899,0.0002902306,0.0001916547,0.0001466291],"domain_scores_gemma":[0.9994115,0.00005445525,0.0002522137,0.0001224671,0.0001078972,0.00005142663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000009363863,0.00004068238,0.03698528,0.000005840473,0.0001020549,0.000001481014,0.0001464108,0.000001089123,0.9540244,0.00007804514,0.000434776,0.00817053],"study_design_scores_gemma":[0.00003226884,0.00004009745,0.9021079,0.00001752396,0.0001834386,0.00002269019,0.00008171427,0.0005611648,0.09237906,0.0002228431,0.004243365,0.0001079547],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982983,0.00001572624,0.000002873568,0.0003468975,0.0004319907,0.0001040851,0.00003976911,0.000008653265,0.0007516913],"genre_scores_gemma":[0.9996713,0.000006618588,0.00001871446,0.00003432872,0.00003764433,0.000001556263,0.00001747354,4.1186e-7,0.0002119589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8651226,"threshold_uncertainty_score":0.3039838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085571769018107,"score_gpt":0.2078061314555884,"score_spread":0.1969504137654073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}