{"id":"W2805934314","doi":"10.1080/21691401.2018.1476375","title":"Long term safety and immunological effects of a nanobiotherapeutic, bovine poly-[hemoglobin-catalase-superoxide dismutase-carbonic anhydrase], after four weekly 5% blood volume top-loading followed by a challenge of 30% exchange transfusion","year":2018,"lang":"en","type":"article","venue":"Artificial Cells Nanomedicine and Biotechnology","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Superoxide dismutase; Carbonic anhydrase; Catalase; Hemoglobin; Chemistry; Blood urea nitrogen; Andrology; Medicine; Immunology; Biochemistry; Enzyme; Creatinine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001882915,0.000303917,0.0005236478,0.0001519486,0.00009933502,0.000008000263,0.0001533251,0.0007631761,0.00005815577],"category_scores_gemma":[0.00003973654,0.0002486975,0.00008743566,0.0002123462,0.000941799,0.00001111261,0.0001444348,0.0001891512,0.000003151209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001337635,"about_ca_system_score_gemma":0.0000334868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007224906,"about_ca_topic_score_gemma":0.00007659364,"domain_scores_codex":[0.9983215,0.00007377242,0.0004846103,0.0005851855,0.0001343222,0.0004006337],"domain_scores_gemma":[0.9992763,0.00003603548,0.0001584541,0.0003804279,0.00005846227,0.00009036295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009233363,0.0001711607,0.002170423,0.0001780791,0.0001295783,0.000022929,0.0001259055,1.272829e-8,0.9524101,0.00001607284,0.00005489609,0.0437975],"study_design_scores_gemma":[0.001698388,0.006474063,0.002720829,0.0001004553,0.0002049236,0.00004901269,0.00007173824,0.00001152315,0.9848244,0.00003952481,0.003554479,0.0002506978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812235,0.01596291,0.0008795928,0.001102832,0.0002528715,0.0004387906,0.00006486646,0.0000319068,0.00004269635],"genre_scores_gemma":[0.9922253,0.007084839,0.0001036622,0.000177425,0.0002003713,0.00001701222,0.00006562794,0.00002601559,0.00009970807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04354681,"threshold_uncertainty_score":0.9999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004333096034111921,"score_gpt":0.1995725998765034,"score_spread":0.1952395038423915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}