{"id":"W2805934314","doi":"10.1080/21691401.2018.1476375","title":"Long term safety and immunological effects of a nanobiotherapeutic, bovine poly-[hemoglobin-catalase-superoxide dismutase-carbonic anhydrase], after four weekly 5% blood volume top-loading followed by a challenge of 30% exchange transfusion","year":2018,"lang":"en","type":"article","venue":"Artificial Cells Nanomedicine and Biotechnology","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Superoxide dismutase; Carbonic anhydrase; Catalase; Hemoglobin; Chemistry; Blood urea nitrogen; Andrology; Medicine; Immunology; Biochemistry; Enzyme; Creatinine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456328,0.0003656085,0.000262913,0.0001592768,0.0001095293,0.0001983152,0.0001713352,0.0003463741,0.0006789248],"category_scores_gemma":[0.0002614936,0.00008625296,0.0002549775,0.00009065471,0.000241147,0.0002567505,0.00009823035,0.0005311878,0.0001606392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130439,"about_ca_system_score_gemma":0.0001472611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002687197,"about_ca_topic_score_gemma":0.0003854344,"domain_scores_codex":[0.9998485,0.00002634238,0.00001340307,0.00003089786,0.00004695921,0.00003391608],"domain_scores_gemma":[0.9996389,0.00004872989,0.0001494347,0.0000477916,0.00005798545,0.00005711577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001623906,0.0005084525,0.0006855306,0.00004204617,0.00001637398,0.00005518454,0.00003030457,0.0001023312,0.9925104,0.00002821086,0.00006490835,0.004332313],"study_design_scores_gemma":[0.00005243185,0.02174218,0.008515458,0.0000068257,0.00006476574,0.000162491,0.00004316206,0.0004973793,0.9680285,0.00002875142,0.0008484577,0.000009602326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987986,0.0003330741,0.0004648835,0.00003279495,0.00002747778,0.00001566007,0.00007393234,0.0000247203,0.0002288449],"genre_scores_gemma":[0.9968561,0.0003402155,0.0005725917,0.00005449811,0.00002376992,0.00003963782,0.0002645142,0.00001012712,0.001838639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006789248,"threshold_uncertainty_score":0.002271235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004333096034111921,"score_gpt":0.1995725998765034,"score_spread":0.1952395038423915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}