{"id":"W2805982252","doi":"10.1093/brain/awy131","title":"The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics","year":2018,"lang":"en","type":"review","venue":"Brain","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Multiple Sclerosis Society; Canada Research Chairs; Multiple Sclerosis Society of Canada; Hotchkiss Brain Institute; Alberta Innovates; University of Calgary","keywords":"Multiple sclerosis; Microbiome; Blood–brain barrier; Intestinal Microbiome; Tight junction; Inflammatory bowel disease; Pathophysiology; Immune system; Gastrointestinal tract; Intestinal permeability; Disease; Immunology; Biology; Medicine; Intestinal mucosa; Neuroscience; Bioinformatics; Central nervous system; Pathology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00068187,0.0007887081,0.001179161,0.002251005,0.0004529868,0.00122477,0.0008189791,0.001742497,0.003769553],"category_scores_gemma":[0.001045376,0.0001955796,0.0005132423,0.001937188,0.0008620532,0.002024912,0.0009357869,0.002422108,0.001667062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008770127,"about_ca_system_score_gemma":0.001830556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126712,"about_ca_topic_score_gemma":0.00186539,"domain_scores_codex":[0.9997812,0.00004474821,0.00004007965,0.00003351019,0.00007796943,0.00002256166],"domain_scores_gemma":[0.9995012,0.0002377105,0.00006489168,0.0000162156,0.0001270776,0.00005273293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007266143,0.00007229178,0.0002231318,0.02006937,0.00008433504,0.0002979334,0.0001467905,0.0003313743,0.001627093,0.01050884,0.0483285,0.9182377],"study_design_scores_gemma":[0.00001115428,0.00007943518,0.0008208912,0.006143897,0.00008095949,0.001550176,0.0001369485,0.00007772622,0.0002935624,0.006743538,0.9840428,0.00001881509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005640124,0.9983217,0.00008779475,0.0006505024,0.0002684985,0.000002067489,0.000009209251,0.00000581207,0.000597986],"genre_scores_gemma":[0.0005402314,0.9983643,0.0001506158,0.0002575791,0.0002522468,0.000004403443,0.00001211414,0.000001440154,0.0004171055],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003769553,"threshold_uncertainty_score":0.01261038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2033938061915519,"score_gpt":0.3546428987778303,"score_spread":0.1512490925862785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}