{"id":"W2805982252","doi":"10.1093/brain/awy131","title":"The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics","year":2018,"lang":"en","type":"review","venue":"Brain","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Multiple Sclerosis Society; Canada Research Chairs; Multiple Sclerosis Society of Canada; Hotchkiss Brain Institute; Alberta Innovates; University of Calgary","keywords":"Multiple sclerosis; Microbiome; Blood–brain barrier; Intestinal Microbiome; Tight junction; Inflammatory bowel disease; Pathophysiology; Immune system; Gastrointestinal tract; Intestinal permeability; Disease; Immunology; Biology; Medicine; Intestinal mucosa; Neuroscience; Bioinformatics; Central nervous system; Pathology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815563,0.0001915962,0.0004071841,0.00005480608,0.0004651995,0.00004606521,0.0002236651,0.000114796,0.00000197653],"category_scores_gemma":[0.001351578,0.0001119799,0.0001115792,0.0002010476,0.0003935029,0.0000286535,0.0001058281,0.0001730861,0.000006856919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001871126,"about_ca_system_score_gemma":0.00006838555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002029169,"about_ca_topic_score_gemma":0.00002969602,"domain_scores_codex":[0.9988862,0.0001767496,0.0002841421,0.0003870995,0.00004256767,0.0002232772],"domain_scores_gemma":[0.9962098,0.003295119,0.0001424713,0.0002847313,0.00003419364,0.00003365593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008074204,0.000005738678,0.00001535669,0.0002565658,0.000010668,1.366321e-7,0.00007693674,1.845009e-8,0.0003803395,0.001757459,0.002307339,0.9951814],"study_design_scores_gemma":[0.0001269269,0.00005706457,0.0002896541,0.0003299871,0.00004542408,0.00001095859,0.00001693762,0.000006699172,0.00001291936,0.00415364,0.9948277,0.0001220255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002710027,0.9975604,0.0002873185,0.0007215632,0.0003492156,0.0007831198,0.0001408333,0.00002768186,0.0001027989],"genre_scores_gemma":[0.0001841227,0.9972001,0.0001327431,0.001391221,0.0002026553,0.000647179,0.000004991272,0.00002308844,0.0002138398],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950594,"threshold_uncertainty_score":0.4566409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2033938061915519,"score_gpt":0.3546428987778303,"score_spread":0.1512490925862785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}