{"id":"W2806039308","doi":"10.1016/j.clml.2018.05.022","title":"An Open-label, Phase II Trial of Entospletinib (GS-9973), a Selective Spleen Tyrosine Kinase Inhibitor, in Diffuse Large B-cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Gilead Sciences","keywords":"Medicine; Internal medicine; Gastroenterology; Peripheral edema; Anemia; Hypoalbuminemia; Adverse effect; Leukopenia; Hyponatremia; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001994489,0.0009248088,0.002525766,0.0003983493,0.0003950575,0.0001405845,0.001050425,0.000885767,0.0002326135],"category_scores_gemma":[0.001187525,0.0008002249,0.0004362427,0.001241453,0.000813035,0.0005389787,0.0009095193,0.0002769998,0.0002708239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002261968,"about_ca_system_score_gemma":0.003663708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055709,"about_ca_topic_score_gemma":0.0003358005,"domain_scores_codex":[0.9919349,0.0007524148,0.003071926,0.001914109,0.0009556192,0.001371014],"domain_scores_gemma":[0.9942731,0.0009162378,0.001010966,0.001989241,0.0006342186,0.001176198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1561668,0.3573297,0.02387852,0.0001312151,0.0004760197,0.001369284,0.0009844749,2.109196e-7,0.006051957,0.0008525265,0.0115205,0.4412388],"study_design_scores_gemma":[0.6866194,0.06169517,0.1973373,0.0004352687,0.0005041877,0.00007621074,0.0001112555,0.0005379601,0.03148809,0.0001709148,0.0203151,0.0007091924],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989796,0.0003960413,0.00001971776,0.0004913866,0.001173494,0.003456311,0.0003285698,0.0001716595,0.004166842],"genre_scores_gemma":[0.9925147,0.00032048,0.001534046,0.001751723,0.002131963,0.0004799591,0.0004227212,0.0001635369,0.0006808666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5304525,"threshold_uncertainty_score":0.9994448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0460260974443202,"score_gpt":0.3835334315622945,"score_spread":0.3375073341179743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}