{"id":"W2806061103","doi":"10.1101/333633","title":"Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan; University of Alberta","funders":"","keywords":"Transcriptome; Chromosome instability; Biology; Tumor microenvironment; Gene; Tumor progression; Hypoxia (environmental); Genome instability; Cancer research; Tumor initiation; Gene expression; Cancer; Chromosome; Genetics; Carcinogenesis; DNA damage; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278871,0.0001006445,0.0001227693,0.0002927607,0.00011444,0.0002737021,0.00008566932,0.0001272236,0.001361169],"category_scores_gemma":[0.0003113618,0.00005883897,0.0001326234,0.0002836282,0.0001547359,0.0001160195,0.0001211723,0.0002133065,0.000195425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435671,"about_ca_system_score_gemma":0.00009168597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004827197,"about_ca_topic_score_gemma":0.0006504274,"domain_scores_codex":[0.9998997,0.0000125475,0.000007146883,0.00002973634,0.00002363552,0.00002724441],"domain_scores_gemma":[0.9998566,0.00004261264,0.00004932683,0.00001562603,0.0000182669,0.00001758856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002038794,0.00002048425,0.06524891,0.00003016971,0.00002142767,0.0001180386,0.00005403998,0.0002699274,0.9293104,0.0001667539,0.00006217271,0.004493825],"study_design_scores_gemma":[0.000005343777,0.0001460037,0.7531011,0.000005090108,0.0000324768,0.0007134634,0.0001681945,0.002891866,0.2413535,0.0003193052,0.001258648,0.000005085092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967844,0.0002075888,0.001715107,0.00005360177,0.000003681202,0.000004948816,0.0005896756,0.00001706034,0.0006240049],"genre_scores_gemma":[0.9981008,0.00007269346,0.000884099,0.00002328875,0.000003663005,0.000005596032,0.0004705416,0.000005647775,0.000433649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361169,"threshold_uncertainty_score":0.004553556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548332466222959,"score_gpt":0.2411372796130087,"score_spread":0.2256539549507791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}