{"id":"W2806074738","doi":"10.1200/edbk_199665","title":"Moving From Mutation to Actionability","year":2018,"lang":"en","type":"review","venue":"American Society of Clinical Oncology Educational Book","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Mutation; Genetics; Computer science; Psychology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005793397,0.000231902,0.001282217,0.00002347099,0.00006511731,0.000008910637,0.000323284,0.0004261666,0.0002483701],"category_scores_gemma":[0.001686402,0.000227362,0.001105238,0.0001312647,0.0008409653,0.000003508504,0.0001827994,0.0002571227,0.00007922603],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958629,"about_ca_system_score_gemma":0.005815374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002402814,"about_ca_topic_score_gemma":0.00004173013,"domain_scores_codex":[0.9975365,0.0002357189,0.001222319,0.0006680822,0.0001522453,0.0001851728],"domain_scores_gemma":[0.9955198,0.00229126,0.001169054,0.0004727024,0.0003382887,0.0002088679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003004134,0.0003109213,0.0001737223,0.0001742365,0.0003438485,1.295321e-7,0.00005023235,0.000003909222,0.000009141465,0.00003618298,0.1565681,0.8422996],"study_design_scores_gemma":[0.000146047,0.0007620615,0.001135525,0.0001714222,0.0002700671,0.00000245292,0.00008008289,0.000002684563,0.000008996868,0.00017475,0.9970329,0.0002129776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002215867,0.9894517,0.0006518616,0.003633949,0.001374393,0.000668802,0.0004138358,0.000008310485,0.001581303],"genre_scores_gemma":[0.00008470161,0.9682221,0.01877768,0.005877258,0.003996172,0.0001521618,0.001145742,0.0000331795,0.001710982],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8420866,"threshold_uncertainty_score":0.9998207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07876465480636548,"score_gpt":0.4844489251781276,"score_spread":0.4056842703717621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}