{"id":"W2806127603","doi":"10.1186/s12864-018-4810-y","title":"Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes","year":2018,"lang":"en","type":"article","venue":"BMC Genomics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sigrid Juséliuksen Säätiö; Samfundet Folkhälsan; Vetenskapsrådet; Institute of Genetics; Uppsala Multidisciplinary Center for Advanced Computational Science; Academy of Finland; Royal Society; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto","keywords":"Biology; Centrosome; Cell biology; Gene isoform; Adherens junction; Actin cytoskeleton; Cytoskeleton; Gene; Transcriptome; HEK 293 cells; Genetics; Gene expression; Cell; Cell cycle; Cadherin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882391,0.0001349013,0.0001095529,0.00002611648,0.0003742938,0.00005575877,0.0001025308,0.00008557207,0.00002428605],"category_scores_gemma":[0.00007434632,0.0001017904,0.00004106163,0.00002101599,0.0002151209,0.00000369933,0.0001889593,0.00007793667,0.00001671978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002161626,"about_ca_system_score_gemma":0.00004703693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003373247,"about_ca_topic_score_gemma":0.000217469,"domain_scores_codex":[0.999149,0.00006385962,0.0001273778,0.000296745,0.00008736499,0.0002756304],"domain_scores_gemma":[0.9995171,0.00004716528,0.00004864942,0.0002336441,0.0000500037,0.0001034166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001962964,0.0000131488,0.001232553,0.00001171367,0.0000426991,0.000001507672,0.0001580394,0.0000454878,0.9973195,0.00008047206,0.0005886278,0.0003099444],"study_design_scores_gemma":[0.0005203316,0.0003045685,0.0009628372,0.000006674296,0.0000178728,0.000008722988,0.0002662296,0.001124127,0.9864817,0.00007107841,0.01008257,0.0001532985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972756,0.0009568278,0.001173554,0.0001417958,0.00007802576,0.0001774438,0.00007091396,0.000008270159,0.0001175519],"genre_scores_gemma":[0.996874,0.001194167,0.0003435482,0.0001280662,0.0003729892,0.00001604383,0.00005558792,0.00001925553,0.0009963209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01083782,"threshold_uncertainty_score":0.4150892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177948974707628,"score_gpt":0.2236424367186385,"score_spread":0.2058475392478757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}