{"id":"W2806127603","doi":"10.1186/s12864-018-4810-y","title":"Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes","year":2018,"lang":"en","type":"article","venue":"BMC Genomics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sigrid Juséliuksen Säätiö; Samfundet Folkhälsan; Vetenskapsrådet; Institute of Genetics; Uppsala Multidisciplinary Center for Advanced Computational Science; Academy of Finland; Royal Society; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto","keywords":"Biology; Centrosome; Cell biology; Gene isoform; Adherens junction; Actin cytoskeleton; Cytoskeleton; Gene; Transcriptome; HEK 293 cells; Genetics; Gene expression; Cell; Cell cycle; Cadherin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100344,0.0003525697,0.0001708042,0.0002864638,0.0002270784,0.0002583732,0.0001399603,0.0002854472,0.002343626],"category_scores_gemma":[0.0001318155,0.0001147269,0.0003132991,0.0001846467,0.0001971303,0.0002317547,0.0001761773,0.0004783139,0.0006413712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002975313,"about_ca_system_score_gemma":0.0001347279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005333099,"about_ca_topic_score_gemma":0.0008742049,"domain_scores_codex":[0.9998147,0.00002428238,0.000009993544,0.00005836695,0.00005716434,0.0000354377],"domain_scores_gemma":[0.9998794,0.00002213322,0.00004122355,0.00001440627,0.00001776625,0.00002510537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007854792,0.000006716884,0.0007612639,0.00002829414,0.000003647664,0.0001541688,0.00001693183,0.00003096176,0.9972988,0.0001142837,0.00003674438,0.001469531],"study_design_scores_gemma":[0.00002648498,0.000188042,0.1090254,0.00001799858,0.00004489566,0.002593657,0.0001343958,0.001397663,0.8823,0.0003271533,0.003933172,0.00001110197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876724,0.001900448,0.005979296,0.0001810381,0.0000209289,0.00002617677,0.0005639732,0.0001665911,0.003489125],"genre_scores_gemma":[0.991015,0.0008407434,0.004567036,0.00007997587,0.00001189663,0.00003697502,0.0007833986,0.00003119282,0.002633648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343626,"threshold_uncertainty_score":0.007840216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177948974707628,"score_gpt":0.2236424367186385,"score_spread":0.2058475392478757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}