{"id":"W2806141734","doi":"10.1002/cbic.201800247","title":"Diversity‐Oriented Synthesis of Diol‐Based Peptidomimetics as Potential HIV Protease Inhibitors and Antitumor Agents","year":2018,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval","funders":"Réseau Québécois de Recherche sur les Médicaments","keywords":"Peptidomimetic; Protease; HIV-1 protease; Docking (animal); Chemistry; Combinatorial chemistry; Human immunodeficiency virus (HIV); Stereochemistry; Diol; Enzyme; Biochemistry; Biology; Virology; Organic chemistry; Medicine; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559076,0.0003304248,0.0002197752,0.0003155963,0.0001180162,0.0002570417,0.00028378,0.0002438061,0.001600772],"category_scores_gemma":[0.0001329877,0.0001465625,0.0001236638,0.0003719192,0.0001493954,0.0003547993,0.0002945219,0.000506697,0.000658202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041516,"about_ca_system_score_gemma":0.000307587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001657392,"about_ca_topic_score_gemma":0.000509002,"domain_scores_codex":[0.9999189,0.00001247584,0.00000790355,0.00001300046,0.00001894022,0.00002873615],"domain_scores_gemma":[0.9999515,0.000005416176,0.00001177799,0.000005804688,0.00000811224,0.00001743178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658729,0.0001040073,0.0001467106,0.0001936078,0.0000129512,0.0002975398,0.00005435412,0.002197771,0.9732068,0.004751467,0.000343641,0.01852517],"study_design_scores_gemma":[0.000151047,0.001093874,0.000781301,0.00002662052,0.00002958636,0.0004254838,0.00004036654,0.004254538,0.967684,0.001352472,0.02412711,0.00003368553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8963954,0.007309055,0.06265147,0.0005265986,0.0003165636,0.0005873228,0.00135557,0.0002628714,0.03059516],"genre_scores_gemma":[0.9426147,0.005764514,0.04557073,0.0002625432,0.00004516964,0.0001677859,0.0006010044,0.00003997071,0.004933658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600772,"threshold_uncertainty_score":0.00535512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009539200868366545,"score_gpt":0.214110647928209,"score_spread":0.2045714470598425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}