{"id":"W2806141734","doi":"10.1002/cbic.201800247","title":"Diversity‐Oriented Synthesis of Diol‐Based Peptidomimetics as Potential HIV Protease Inhibitors and Antitumor Agents","year":2018,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval","funders":"Réseau Québécois de Recherche sur les Médicaments","keywords":"Peptidomimetic; Protease; HIV-1 protease; Docking (animal); Chemistry; Combinatorial chemistry; Human immunodeficiency virus (HIV); Stereochemistry; Diol; Enzyme; Biochemistry; Biology; Virology; Organic chemistry; Medicine; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001421991,0.0003007638,0.0003833726,0.00006352981,0.0003851209,0.00002567377,0.0002856603,0.0002294163,0.001296874],"category_scores_gemma":[0.000505547,0.0003163744,0.0001885833,0.0001919162,0.0005705751,0.00007674865,0.0005702992,0.0001519494,0.00003492482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006251592,"about_ca_system_score_gemma":0.00007556364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003668704,"about_ca_topic_score_gemma":5.286057e-7,"domain_scores_codex":[0.9984331,0.00001841365,0.000346025,0.0005118567,0.0003478273,0.0003427487],"domain_scores_gemma":[0.9987236,0.00009163431,0.0002274634,0.000524401,0.000190901,0.0002419514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002561698,0.0002426319,0.004923942,0.00046475,0.00009465404,0.00003691426,0.0002530662,8.930035e-7,0.9925551,0.0000116902,0.0007763228,0.0003838668],"study_design_scores_gemma":[0.0007671241,0.00002322244,0.0001520242,0.0002116199,0.0001863545,0.00001294375,0.0003679908,0.0003665797,0.9970307,0.00003326982,0.0005170338,0.0003310936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988064,0.00006572278,0.00004099555,0.0001079923,0.00007639616,0.000109274,0.00009480657,0.00007977883,0.01136102],"genre_scores_gemma":[0.9982055,0.00001406648,0.0002331633,0.00003303049,0.0003207242,0.00002080904,0.00003468719,0.00003295957,0.001105037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025598,"threshold_uncertainty_score":0.9999288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009539200868366545,"score_gpt":0.214110647928209,"score_spread":0.2045714470598425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}