{"id":"W2806192388","doi":"10.1128/aac.00461-18","title":"Few Conserved Amino Acids in the Small Multidrug Resistance Transporter EmrE Influence Drug Polyselectivity","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Multiple drug resistance; Transporter; Drug resistance; Amino acid; Substrate specificity; Biology; Drug; Chemistry; Genetics; Biochemistry; Pharmacology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171286,0.000257115,0.0002142694,0.0001711715,0.00009054654,0.000222578,0.0001562493,0.0002091856,0.0009746681],"category_scores_gemma":[0.0002986348,0.0001145994,0.0001669335,0.0001987273,0.0002345018,0.0001346625,0.0001849397,0.0002328988,0.0002791729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211887,"about_ca_system_score_gemma":0.0001166732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007028821,"about_ca_topic_score_gemma":0.001713486,"domain_scores_codex":[0.999811,0.00005834014,0.00002208096,0.00003053622,0.00004944808,0.00002859945],"domain_scores_gemma":[0.9998233,0.00004544934,0.00005938632,0.00002051933,0.00002712388,0.00002421904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007162102,0.00001312391,0.00122904,0.00001149827,0.000009322582,0.00005371841,0.000008030447,0.0001296676,0.9973208,0.00003745685,0.00001119287,0.00110461],"study_design_scores_gemma":[0.00001302628,0.0002664404,0.02416145,0.000005939811,0.00003678458,0.0006157301,0.00004547547,0.001909387,0.9717649,0.00003666088,0.001135287,0.000008851281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983343,0.0001489954,0.0009188629,0.00002026725,0.00000279033,0.000007759504,0.00009317468,0.0000148295,0.0004589806],"genre_scores_gemma":[0.9986394,0.00006427912,0.00075863,0.0000175814,0.000001071666,0.000003152074,0.0002063093,0.000009173327,0.000300336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009746681,"threshold_uncertainty_score":0.003260553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028602118167159,"score_gpt":0.2319254047684748,"score_spread":0.2216393835868032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}