{"id":"W2806192388","doi":"10.1128/aac.00461-18","title":"Few Conserved Amino Acids in the Small Multidrug Resistance Transporter EmrE Influence Drug Polyselectivity","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Multiple drug resistance; Transporter; Drug resistance; Amino acid; Substrate specificity; Biology; Drug; Chemistry; Genetics; Biochemistry; Pharmacology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005751,0.0002277834,0.0002044497,0.00003321127,0.0001936515,0.00007417468,0.000251963,0.0001048521,0.00002479435],"category_scores_gemma":[0.00001015449,0.0001625853,0.00008738116,0.0001149367,0.0002727396,0.00001425941,0.00002604496,0.0001045467,0.000003231053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006809722,"about_ca_system_score_gemma":0.00003351115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002221072,"about_ca_topic_score_gemma":0.002017645,"domain_scores_codex":[0.9989324,0.00007642328,0.0002126235,0.0003854588,0.00008843868,0.0003046221],"domain_scores_gemma":[0.9995269,0.000019513,0.00008161431,0.0002761853,0.00005454909,0.00004127951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004876643,0.0003415915,0.1230623,0.00006150704,0.00007180229,0.0000085294,0.002106516,0.000001582687,0.8584647,0.00004706649,0.01199074,0.003355934],"study_design_scores_gemma":[0.001514996,0.0001093207,0.5347031,0.00008408605,0.00002120047,0.0000153016,0.0001963263,0.00001791132,0.3391666,0.00006833389,0.1236732,0.0004296426],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966248,0.0001075261,0.00006907331,0.002459955,0.0000714826,0.0001993186,0.00002898377,0.00001099341,0.00042789],"genre_scores_gemma":[0.9875296,0.0006285483,0.0001747203,0.01037459,0.0002735535,0.00001096399,0.00002109011,0.00002277866,0.0009641548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5192981,"threshold_uncertainty_score":0.6630035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028602118167159,"score_gpt":0.2319254047684748,"score_spread":0.2216393835868032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}