{"id":"W2806233947","doi":"10.1158/1541-7786.mcr-17-0649","title":"The Hypoxic Tumor Microenvironment Promotes Invadopodia Formation and Metastasis through LPA1 Receptor and EGFR Cooperation","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Invadopodia; Lysophosphatidic acid; Cancer research; Metastasis; Cancer cell; PI3K/AKT/mTOR pathway; Proto-oncogene tyrosine-protein kinase Src; Tumor microenvironment; Protein kinase B; Cell biology; Hypoxia (environmental); Biology; Phosphorylation; Receptor; Cancer; Signal transduction; Chemistry; Medicine; Internal medicine; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133173,0.0002015286,0.0001793856,0.0002370921,0.0001597952,0.0002599999,0.0001226469,0.0001897122,0.001847735],"category_scores_gemma":[0.0000586856,0.0001239302,0.0002087915,0.00008985148,0.0001528358,0.0001944885,0.0002662112,0.0004193308,0.0005318352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338926,"about_ca_system_score_gemma":0.0002026673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005296912,"about_ca_topic_score_gemma":0.0005179353,"domain_scores_codex":[0.9999247,0.00001339152,0.000003471526,0.000009673248,0.00001591285,0.00003294145],"domain_scores_gemma":[0.9999456,0.000006474553,0.00001483437,0.000004413064,0.000006080957,0.00002258393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001912849,0.00007122982,0.0005882948,0.0000293454,0.000004568856,0.0001786319,0.00001277324,0.00006411628,0.9969869,0.0002733517,0.0001568193,0.001442728],"study_design_scores_gemma":[0.00008890259,0.0006750462,0.06316936,0.00001773488,0.00003541819,0.00174054,0.0001468038,0.004381155,0.9214966,0.0004236919,0.007812699,0.00001216518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937055,0.002027453,0.001409998,0.0002196254,0.00001822245,0.00002086432,0.0001536771,0.00005918087,0.002385539],"genre_scores_gemma":[0.9954854,0.0007907156,0.0007204514,0.00003657892,0.00001061019,0.00002629329,0.0001967183,0.000005680329,0.00272757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847735,"threshold_uncertainty_score":0.0061813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449655194386647,"score_gpt":0.3298714861050686,"score_spread":0.2953749341612021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}