{"id":"W2806233947","doi":"10.1158/1541-7786.mcr-17-0649","title":"The Hypoxic Tumor Microenvironment Promotes Invadopodia Formation and Metastasis through LPA1 Receptor and EGFR Cooperation","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Invadopodia; Lysophosphatidic acid; Cancer research; Metastasis; Cancer cell; PI3K/AKT/mTOR pathway; Proto-oncogene tyrosine-protein kinase Src; Tumor microenvironment; Protein kinase B; Cell biology; Hypoxia (environmental); Biology; Phosphorylation; Receptor; Cancer; Signal transduction; Chemistry; Medicine; Internal medicine; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007453627,0.0001168271,0.0001000916,0.00003410945,0.0005269819,0.0001516844,0.0001395448,0.0000559593,0.00002414388],"category_scores_gemma":[0.0001361953,0.00008762211,0.00002689796,0.0001176438,0.0004037756,0.00001721504,0.0002028602,0.0001232377,0.000009003821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002715094,"about_ca_system_score_gemma":0.00006374485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001287864,"about_ca_topic_score_gemma":0.00009457055,"domain_scores_codex":[0.9987081,0.0002371594,0.0001594222,0.0003193906,0.0002532339,0.0003226405],"domain_scores_gemma":[0.9994685,0.00002083393,0.0000421108,0.0002590586,0.0001370781,0.00007242075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007582676,0.00001312673,0.00009861773,0.000020247,0.0000338071,0.000001214366,0.0002623523,0.000003119687,0.9904617,0.0002471856,0.0009754413,0.00780738],"study_design_scores_gemma":[0.0003444417,0.0001710464,0.0001883232,0.00001630573,0.00001293322,0.000009012794,0.0001715566,0.00010337,0.8880695,0.0001132566,0.1107005,0.00009970037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820047,0.01485333,0.001621323,0.0008814969,0.00007782593,0.0004008757,0.00001624215,0.000005647116,0.0001385493],"genre_scores_gemma":[0.993395,0.0047194,0.000951954,0.0003271614,0.0002665867,0.0001455809,0.00003316128,0.00002215225,0.0001390333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097251,"threshold_uncertainty_score":0.4053172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449655194386647,"score_gpt":0.3298714861050686,"score_spread":0.2953749341612021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}