{"id":"W2806244397","doi":"10.1016/j.biologicals.2018.05.006","title":"Host cell protein testing strategy for hepatitis B antigen in Hexavalent vaccine – Towards a general testing strategy for recombinant vaccines","year":2018,"lang":"en","type":"article","venue":"Biologicals","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Virology; Recombinant DNA; Antigen; Biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000857555,0.0004123141,0.0008970134,0.0001406498,0.0002684726,0.00004766468,0.0001985183,0.0002565207,0.00007383436],"category_scores_gemma":[0.003906406,0.0002913162,0.0001357016,0.0004398476,0.00007689394,0.00008346126,0.000125179,0.0001704213,0.0000207098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308257,"about_ca_system_score_gemma":0.0002249535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003710185,"about_ca_topic_score_gemma":0.001736345,"domain_scores_codex":[0.9971852,0.0001140986,0.0008848635,0.0007600495,0.0001590882,0.0008967351],"domain_scores_gemma":[0.9979392,0.0005249024,0.0003009896,0.0003067621,0.000764232,0.0001639567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003585864,0.0005099848,0.7276911,0.0004233677,0.00006200151,0.00004460289,0.00007932379,0.0000134184,0.2213858,0.0001522704,0.001383884,0.04789565],"study_design_scores_gemma":[0.003795514,0.01419009,0.9295134,0.0005053791,0.00005851998,0.0000257077,0.00005912653,0.003737738,0.04355909,0.00140363,0.002602164,0.000549657],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918412,0.0008283567,0.0005434548,0.0005085883,0.0002093156,0.004382225,0.0001423018,0.0001760245,0.001368561],"genre_scores_gemma":[0.9624603,0.0001782226,0.03420322,0.0002667391,0.0008681779,0.001229353,0.0000636168,0.00004659385,0.0006837964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2018223,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539994539342484,"score_gpt":0.352587865346864,"score_spread":0.1985884114126156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}