{"id":"W2806319892","doi":"10.1038/s41598-018-26603-1","title":"The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec; Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Genentech; McGill University; Burroughs Wellcome Fund","keywords":"AIM2; Protease; Biology; Virology; Cell biology; Chemistry; Inflammasome; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002440617,0.0002159824,0.0003122304,0.0001592432,0.0001367081,0.0005547683,0.000152697,0.0003130584,0.0006661625],"category_scores_gemma":[0.0002203323,0.0001124191,0.0002557673,0.0001213149,0.0002410833,0.0003941681,0.0003219895,0.0003915424,0.0003611195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077906,"about_ca_system_score_gemma":0.0002034375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002516418,"about_ca_topic_score_gemma":0.0004079088,"domain_scores_codex":[0.9997241,0.0000573861,0.00004296602,0.00005723394,0.00007338759,0.00004489311],"domain_scores_gemma":[0.9997938,0.00003309172,0.00005830076,0.00004095428,0.00003139438,0.00004252273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007988083,0.000007316633,0.0002398482,0.00002557456,0.000005778144,0.00005189198,0.00000781832,0.00004742126,0.9986221,0.00008012063,0.0000324235,0.0007998057],"study_design_scores_gemma":[0.00003193141,0.0003173946,0.009935196,0.00001049089,0.00002653842,0.001325957,0.00003966234,0.001042731,0.9820535,0.0001720322,0.005037328,0.000007076024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980789,0.008968504,0.007111773,0.0003028352,0.00004534756,0.00002677957,0.0003521068,0.0001385177,0.002265082],"genre_scores_gemma":[0.9951105,0.001190491,0.00217353,0.00008721108,0.00002429685,0.00001498751,0.0002342483,0.00001467373,0.001150079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006661625,"threshold_uncertainty_score":0.002228558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005356292330615774,"score_gpt":0.2233123848673118,"score_spread":0.217956092536696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}