{"id":"W2806422799","doi":"10.1186/s12987-018-0100-y","title":"Zika virus crosses an in vitro human blood brain barrier model","year":2018,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Public Health Agency; Public Health Agency of Canada; University of Ottawa","keywords":"Blood–brain barrier; Induced pluripotent stem cell; Zika virus; Progenitor cell; Neural stem cell; Biology; Flavivirus; Central nervous system; Virology; In vitro; Neuroscience; Cell biology; Human brain; Stem cell; Immunology; Virus; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447839,0.0003465614,0.0002646082,0.0001917925,0.0002323339,0.0004378337,0.0002851371,0.0003752776,0.001438648],"category_scores_gemma":[0.0001616304,0.000188021,0.0002737105,0.0001150775,0.0001656645,0.0003198067,0.0002791556,0.001073762,0.0005211145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453956,"about_ca_system_score_gemma":0.0002269237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002530127,"about_ca_topic_score_gemma":0.002372229,"domain_scores_codex":[0.9997148,0.00005390659,0.0000298881,0.00006847839,0.00008948061,0.00004335306],"domain_scores_gemma":[0.9998951,0.00002426466,0.00001991731,0.00002034244,0.00002760618,0.0000127288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005373531,0.00004233271,0.0002099153,0.00006469698,0.00001383675,0.00009293753,0.00006530683,0.0001259733,0.9976451,0.0004191345,0.0001482564,0.001118823],"study_design_scores_gemma":[0.00000939586,0.0003392454,0.00155446,0.00002077818,0.00005653097,0.0003912923,0.00005522528,0.002749067,0.9886172,0.0001712513,0.006027424,0.000008102659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9460143,0.004660036,0.03687453,0.0003089797,0.0003237944,0.0002812909,0.001530323,0.000285203,0.009721539],"genre_scores_gemma":[0.9730329,0.003361126,0.01648406,0.0001555592,0.0000273904,0.0001883769,0.001880027,0.00003906628,0.004831556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002530127,"threshold_uncertainty_score":0.005030751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105103420928511,"score_gpt":0.2760445455235021,"score_spread":0.265534203430651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}