{"id":"W2806433337","doi":"10.1038/s41598-018-19522-8","title":"A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Transcytosis; Blood–brain barrier; Induced pluripotent stem cell; Cell biology; Biology; Neural stem cell; Antibody; Receptor; Stem cell; Immunology; Central nervous system; Neuroscience; Embryonic stem cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195858,0.0002639601,0.0001528467,0.000178264,0.0001004536,0.0002229773,0.0002034082,0.0003336749,0.0005481944],"category_scores_gemma":[0.0001212328,0.00009670233,0.0001590317,0.00008654148,0.0001908736,0.0002454397,0.0001694169,0.0004066849,0.0001442341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347821,"about_ca_system_score_gemma":0.0001548708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004857756,"about_ca_topic_score_gemma":0.0004277574,"domain_scores_codex":[0.9999211,0.00001576732,0.000008558974,0.00001923339,0.00002660439,0.000008746299],"domain_scores_gemma":[0.9999349,0.00001349564,0.0000181773,0.000009537026,0.00001297535,0.0000109122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001918948,0.00001371978,0.0001045071,0.00004005458,0.000003818157,0.00005942359,0.00001570287,0.0001639787,0.9977677,0.0003752776,0.00004432856,0.001392392],"study_design_scores_gemma":[0.000009972161,0.0002914587,0.001245488,0.00000894395,0.00002671036,0.0005512584,0.00002119329,0.004187666,0.9891621,0.0002300487,0.004257348,0.00000765434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8614138,0.004116749,0.1300131,0.000292056,0.0001506898,0.0002033128,0.001048904,0.0003274983,0.002433935],"genre_scores_gemma":[0.9576696,0.002004558,0.03842907,0.00008722365,0.00001583355,0.0001114203,0.0006436313,0.00002804531,0.001010742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005481944,"threshold_uncertainty_score":0.001833856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357160623383231,"score_gpt":0.2937800024154494,"score_spread":0.2502083961816171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}