{"id":"W2806439974","doi":"10.4049/jimmunol.1701440","title":"TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"GLUT1; Protein kinase B; PI3K/AKT/mTOR pathway; Glucose transporter; Cell biology; Phosphorylation; Phosphatidylinositol; Kinase; Intracellular; Phosphoinositide 3-kinase; Signal transduction; Chemistry; Biology; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009918422,0.0003751307,0.0002313937,0.0001935139,0.0002460188,0.000613343,0.0003218284,0.0003787189,0.001065201],"category_scores_gemma":[0.00008298185,0.0001550573,0.0001591585,0.0001419059,0.0002764037,0.0005175849,0.000446689,0.000658468,0.0003341926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003246357,"about_ca_system_score_gemma":0.0002240365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001525263,"about_ca_topic_score_gemma":0.0001885395,"domain_scores_codex":[0.9999092,0.00001053631,0.000005592751,0.00002729991,0.00002145266,0.0000258948],"domain_scores_gemma":[0.9999319,0.000005746943,0.00001777649,0.000008098817,0.000008531098,0.00002792828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353213,0.00001239776,0.000219401,0.00002939034,0.00000429924,0.0001131555,0.00001100575,0.0001156528,0.9949418,0.000662489,0.0001345563,0.003620625],"study_design_scores_gemma":[0.00009226937,0.0003051915,0.01077619,0.00001737153,0.00005991184,0.0009738347,0.00007460055,0.005542777,0.9700322,0.001876326,0.01023202,0.00001741173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726313,0.005612112,0.01501686,0.0007175984,0.0001505518,0.00003621299,0.0004480311,0.0007950229,0.004592265],"genre_scores_gemma":[0.9916717,0.001811581,0.003479384,0.0001645401,0.00007019816,0.00004124982,0.0001961408,0.000041526,0.002523635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065201,"threshold_uncertainty_score":0.003563404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017331388641436,"score_gpt":0.2204785465467195,"score_spread":0.2103052326603052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}