{"id":"W2806484916","doi":"10.1101/340851","title":"Different SUMO Paralogs Determine the Fate of WT and Mutant CFTRs: Biogenesis vs. Degradation","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; Carnegie Mellon University; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Biogenesis; Ubiquitin ligase; Ubiquitin; Mutant; SUMO protein; Cycloheximide; Cell biology; RNF4; Chemistry; Gene knockdown; Protein degradation; Molecular biology; SUMO enzymes; Biology; Wild type; Biochemistry; Transcription factor; Protein biosynthesis; Gene; Zinc finger","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741075,0.0001745242,0.0002132646,0.0001612743,0.0001556643,0.0004076815,0.0001263104,0.0003103175,0.0009243301],"category_scores_gemma":[0.0001431195,0.0001534295,0.0002370833,0.0001145047,0.0002184444,0.0003285962,0.0001465799,0.0004334472,0.0003739689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371218,"about_ca_system_score_gemma":0.0001147463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003426147,"about_ca_topic_score_gemma":0.0004007828,"domain_scores_codex":[0.9998519,0.0000182681,0.00001720495,0.00003967566,0.00004136939,0.0000316176],"domain_scores_gemma":[0.9998801,0.00002394842,0.00003231679,0.0000147006,0.00002292915,0.00002610054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005553438,0.000003685595,0.0003677103,0.000006706308,0.000001567115,0.00001506982,0.000004842397,0.00002303605,0.9991301,0.00004063396,0.000009209573,0.0003420322],"study_design_scores_gemma":[0.000002271147,0.00004803663,0.009010997,0.000001416101,0.000004610374,0.0001288479,0.00002724006,0.000628226,0.9897216,0.00004495429,0.0003793201,0.000002515379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950563,0.0006474105,0.003154817,0.00008124293,0.00001691051,0.000009503048,0.0003613243,0.00006403181,0.0006084069],"genre_scores_gemma":[0.9969246,0.0002809093,0.001354707,0.00003694052,0.000003159056,0.00001007355,0.0002371676,0.00001708791,0.001135253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009243301,"threshold_uncertainty_score":0.00309217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162184107971285,"score_gpt":0.2197506867248505,"score_spread":0.203532275927722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}