{"id":"W2806504012","doi":"10.1038/s41588-018-0142-8","title":"Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci","year":2018,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1010,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre","funders":"Servicio Gallego de Salud; Cancer Council Queensland; Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Warwick Medical School; Turun Yliopistollinen Keskussairaala; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Tampereen Yliopisto; National Heart, Lung, and Blood Institute; Peter MacCallum Cancer Centre; Karolinska Institutet; DOD Prostate Cancer Research Program; Cambridge University Hospitals; Queensland University of Technology; Griffith University; National Cancer Institute; University of Bristol; Monash Biomedicine Discovery Institute, Monash University; University of Oxford; University of Warwick; Harvard T.H. Chan School of Public Health; Aarhus Universitetshospital; National Institute for Health and Care Research; Breast Cancer Research Foundation; University of Cambridge; University College London; University of Southern California; Cancer Research UK; Monash University; Australian Prostate Cancer Research; Tays; Institut for Klinisk Medicin, Aarhus Universitet; Prostate Cancer Foundation of Australia; Ovarian Cancer Research Fund; Case Western Reserve University; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; Uppsala Universitet; Prostate Cancer Foundation; European Commission; U.S. Department of Defense; Turun Yliopisto; Aarhus Universitet; National Health and Medical Research Council; Cancer Research Institute","keywords":"Biology; Prostate cancer; Genetics; Cancer; Genome-wide association study; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001799408,0.0005243564,0.0007703629,0.001181134,0.0007907015,0.0009266192,0.000600839,0.0007147054,0.002363138],"category_scores_gemma":[0.004738642,0.0005158586,0.001140589,0.003753022,0.000557031,0.0004224863,0.0006913128,0.0008630164,0.0004894566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474055,"about_ca_system_score_gemma":0.0005859997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00514886,"about_ca_topic_score_gemma":0.008646797,"domain_scores_codex":[0.9986249,0.0003201227,0.0001202416,0.0004170634,0.0003572357,0.0001604597],"domain_scores_gemma":[0.9964021,0.001596066,0.0008733628,0.0004744084,0.0002881972,0.0003657971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004017878,0.00005841081,0.9878815,0.00004197451,0.0006475818,0.0002215855,0.0001197429,0.00009235091,0.002414732,0.00009411393,0.0005503484,0.00747591],"study_design_scores_gemma":[0.0000290324,0.00006911308,0.9973502,0.000006423946,0.0003007193,0.0004280275,0.00005892677,0.0001239308,0.0003859368,0.0001412061,0.00109892,0.000007385115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916169,0.003637321,0.001281332,0.0002947704,0.00004464522,0.00001674416,0.001820424,0.00006200315,0.001225798],"genre_scores_gemma":[0.996075,0.0008287561,0.0008753759,0.0001402328,0.00004946244,0.00001554923,0.001259249,0.0000248704,0.0007314674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00514886,"threshold_uncertainty_score":0.01023775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840118287026318,"score_gpt":0.3611872945883806,"score_spread":0.3427861117181174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}