{"id":"W2806512695","doi":"10.1016/j.atherosclerosissup.2018.04.029","title":"Whole-gene Duplication of PCSK9 as a Novel Genetic Mechanism for Familial Hypercholesterolemia","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Western University","funders":"","keywords":"AMPK; Skeletal muscle; PI3K/AKT/mTOR pathway; mTORC1; Autophagy; Endocrinology; Internal medicine; AMP-activated protein kinase; Medicine; Glycolysis; Endurance training; Insulin resistance; Protein kinase A; Biology; Kinase; Insulin; Metabolism; Cell biology; Biochemistry; Signal transduction; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708283,0.0002310556,0.0003981998,0.0001007431,0.0001152915,0.00001478723,0.0001965216,0.0001398605,0.0003000608],"category_scores_gemma":[0.00006712543,0.0002169368,0.0001507932,0.0001617379,0.0001078111,0.00008463982,0.00007545283,0.00007978099,0.0001687145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004845915,"about_ca_system_score_gemma":0.00007999663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001942794,"about_ca_topic_score_gemma":0.00003729099,"domain_scores_codex":[0.9982838,0.00001994115,0.0005056756,0.0004322642,0.0003548157,0.000403471],"domain_scores_gemma":[0.9986715,0.00002928674,0.0001875729,0.000571085,0.0003703605,0.0001701808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001365123,0.0003151388,0.00360757,0.00004338836,0.0001083585,2.355389e-7,0.0005514079,2.496871e-7,0.988573,0.0009595928,0.0005475875,0.005156932],"study_design_scores_gemma":[0.007055748,0.001525809,0.111725,0.0001042047,0.0004741198,0.00001513345,0.0001361588,0.0001329925,0.8471949,0.0009804242,0.03040978,0.0002457901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794626,0.00005170424,0.01769184,0.0005290037,0.0003031766,0.001340874,0.0004169819,0.00004638933,0.0001574502],"genre_scores_gemma":[0.9674659,0.00006206769,0.02896805,0.001340223,0.0005244674,0.0002706756,0.0002465816,0.00006952004,0.001052471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1413782,"threshold_uncertainty_score":0.8846427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04132203906298135,"score_gpt":0.3099062070760007,"score_spread":0.2685841680130193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}