{"id":"W2806557979","doi":"10.1016/j.atherosclerosissup.2018.04.061","title":"Postprandial GLP-1 Response to a High-fat Meal is Blunted in Obese Adolescents with Insulin Resistance and Metabolic Dyslipidemia","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"AMPK; Endocrinology; Insulin resistance; Internal medicine; Skeletal muscle; mTORC1; Postprandial; Medicine; FGF21; PI3K/AKT/mTOR pathway; Autophagy; AMP-activated protein kinase; Glycolysis; Adiponectin; Oxidative phosphorylation; Protein kinase A; Insulin; Biology; Kinase; Metabolism; Biochemistry; Signal transduction; Fibroblast growth factor; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005376796,0.0003304178,0.0003227915,0.000183589,0.0001419585,0.00007036601,0.0003806513,0.000176211,0.0001559408],"category_scores_gemma":[0.0001878033,0.000297948,0.00004970693,0.0004376008,0.000206277,0.00001790429,0.0003771638,0.0001766509,0.00008328501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006130871,"about_ca_system_score_gemma":0.00008958631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003285101,"about_ca_topic_score_gemma":0.003239162,"domain_scores_codex":[0.9972358,0.0003486589,0.0003840581,0.000820823,0.0004728484,0.0007377472],"domain_scores_gemma":[0.9988098,0.00002386535,0.00009173342,0.0006122629,0.0001689669,0.0002934319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01442418,0.0001388081,0.1862089,0.00003015693,0.00005492876,0.000002371913,0.0005242909,6.094676e-7,0.7959441,0.000009201686,0.002519309,0.0001431165],"study_design_scores_gemma":[0.005850965,0.001959031,0.5587181,0.0003052774,0.00001850752,0.000001431301,0.00008674844,0.000005491379,0.4200132,0.00001856169,0.01264126,0.0003814691],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978458,0.0001503445,0.0000766555,0.0006989075,0.00008066751,0.0007419278,0.0003532952,0.0000165579,0.00003581637],"genre_scores_gemma":[0.9969637,0.00007841302,0.00131915,0.0008650483,0.0001916679,0.0001114943,0.00006876914,0.00007139341,0.0003303703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3759309,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054906899201701,"score_gpt":0.2690564489898246,"score_spread":0.2585073799978075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}