{"id":"W2806639872","doi":"10.1038/s41598-018-22931-4","title":"Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP84Gly","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Human leukocyte antigen; Antigen presentation; Endogeny; Antigen; Major histocompatibility complex; Antigen processing; CD74; Biology; Endoplasmic reticulum; MHC class II; MHC class I; Computational biology; Cell biology; Genetics; Immune system; Biochemistry; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002889506,0.0002467054,0.0001415064,0.00009440534,0.00009925168,0.0003493262,0.000334497,0.0002961403,0.001433114],"category_scores_gemma":[0.0002635633,0.0001273123,0.0001869253,0.00006550548,0.0003881358,0.0002284481,0.0002783447,0.0006581675,0.0003173284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031382,"about_ca_system_score_gemma":0.0001409907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002488595,"about_ca_topic_score_gemma":0.000114249,"domain_scores_codex":[0.9997426,0.00006465961,0.00002726848,0.00004677394,0.00005704384,0.00006161548],"domain_scores_gemma":[0.9996818,0.00007803628,0.0001206084,0.00005540117,0.00001923132,0.00004501958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005980783,0.00001479158,0.0002962799,0.00001557512,0.000004362161,0.00007315275,0.000006002419,0.00004466606,0.998698,0.0002754061,0.00001444191,0.0004975328],"study_design_scores_gemma":[0.00001485284,0.0001534203,0.00521665,0.000003861746,0.00001139129,0.000765043,0.00002198048,0.0009722956,0.9916746,0.0001610362,0.001001008,0.000003883343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942661,0.0004374217,0.004424792,0.00007124058,0.00001733929,0.000009870916,0.00007081688,0.00002937873,0.0006731159],"genre_scores_gemma":[0.9982964,0.0001197029,0.0009417775,0.00003868783,0.000005336668,0.000009367011,0.00008877582,0.000009946959,0.0004898946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433114,"threshold_uncertainty_score":0.00479424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05114955030650045,"score_gpt":0.2642084748328592,"score_spread":0.2130589245263587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}