{"id":"W2806661427","doi":"10.1101/335612","title":"Longitudinal increase in sleep problems is related to amyloid deposition in cortical regions with high <i>HOMER1</i> gene expression","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sleep and related disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Norges Forskningsråd; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Universitetet i Oslo; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Sleep (system call); Sleep deprivation; Biomarker; Disease; Psychology; Neuroscience; Alzheimer's disease; Biology; Internal medicine; Cognition; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264168,0.0001444195,0.0001696857,0.0004461195,0.0002535194,0.000316148,0.0001060113,0.0001858795,0.001618609],"category_scores_gemma":[0.0003566388,0.0001312416,0.0001780749,0.0003441299,0.0001825247,0.0001413104,0.0002226222,0.0002841512,0.0001861919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009976873,"about_ca_system_score_gemma":0.00007038047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003190258,"about_ca_topic_score_gemma":0.00461526,"domain_scores_codex":[0.9999397,0.000007888563,0.000006783518,0.00002402836,0.000008116254,0.00001350885],"domain_scores_gemma":[0.9995808,0.0000438391,0.0002138844,0.0000335523,0.00005953828,0.00006838464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004089845,0.0000453014,0.9859198,0.00001309298,0.00008723541,0.000119499,0.00009948052,0.00002850257,0.0114883,0.00001149479,0.00007457102,0.001703827],"study_design_scores_gemma":[0.000001222054,0.00004051972,0.9995702,7.98292e-7,0.000007104888,0.00009974778,0.00003133526,0.00003017595,0.000184055,0.000006953374,0.00002719128,6.323634e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994987,0.00009436971,0.00008026372,0.000009552151,0.000001928096,0.000003009303,0.0001717942,0.000003308453,0.0001371018],"genre_scores_gemma":[0.9993986,0.00004891234,0.00005756587,0.00001217079,0.000003330438,0.000004083513,0.000220683,0.000001532249,0.0002530525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003190258,"threshold_uncertainty_score":0.006343365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115612899473992,"score_gpt":0.235213692409044,"score_spread":0.2236524024616448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}