{"id":"W2806680184","doi":"10.1038/s41598-018-22985-4","title":"Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Insulin receptor; Internal medicine; Endocrinology; Basal forebrain; Insulin; Medicine; Striatum; Neuroscience; Psychology; Biology; Insulin resistance; Central nervous system; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002517255,0.001196037,0.0006119031,0.001198663,0.0003737881,0.0003484544,0.0004280877,0.0005854202,0.001697825],"category_scores_gemma":[0.0001529785,0.000436423,0.0004034781,0.0004706454,0.0006170668,0.0004746873,0.0003908886,0.001518025,0.0002931478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005048871,"about_ca_system_score_gemma":0.0005186942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525003,"about_ca_topic_score_gemma":0.003077998,"domain_scores_codex":[0.9997733,0.00002836443,0.00002349852,0.00005961361,0.00005256775,0.00006267164],"domain_scores_gemma":[0.9996977,0.0000166446,0.0001089478,0.0000426185,0.00002119065,0.0001129505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005941537,0.002972772,0.003258766,0.0001266551,0.00007412168,0.001118532,0.0001159419,0.0003240807,0.9793885,0.0005436671,0.0002012585,0.005934077],"study_design_scores_gemma":[0.0005917884,0.03514574,0.0472951,0.00007643458,0.0003107731,0.00424881,0.0003668183,0.005123058,0.902754,0.0008241893,0.003200444,0.0000627847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971728,0.0004852836,0.001281809,0.00008773437,0.00005537677,0.00005898358,0.0001872013,0.00006248352,0.0006082929],"genre_scores_gemma":[0.9920534,0.001093499,0.003213984,0.0000756497,0.0000243732,0.0001738859,0.000402135,0.0000197894,0.002943355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697825,"threshold_uncertainty_score":0.005679846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06719222394954029,"score_gpt":0.328994160861493,"score_spread":0.2618019369119527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}