{"id":"W2806700450","doi":"10.1016/j.atherosclerosissup.2018.04.354","title":"Canagliflozin Directly Reduces Macrophage Inflammation via AMPK in a Mouse Model of Atherosclerosis","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Canagliflozin; Inflammation; AMPK; Macrophage; Medicine; Chemistry; Immunology; Endocrinology; Diabetes mellitus; Biochemistry; Type 2 diabetes; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003402627,0.000353323,0.0005315458,0.0003379107,0.00009660298,0.00003876218,0.0002387774,0.0001197296,0.0005024467],"category_scores_gemma":[0.00003525412,0.0003295298,0.0001598999,0.0004345449,0.0001712211,0.0002908249,0.000165908,0.000115693,0.0001078132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804272,"about_ca_system_score_gemma":0.00005728861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254936,"about_ca_topic_score_gemma":0.001201801,"domain_scores_codex":[0.9975718,0.00005302011,0.0007251007,0.0005158253,0.0005369006,0.000597311],"domain_scores_gemma":[0.9988424,0.00002706355,0.0002660203,0.0005722582,0.0001505703,0.0001416434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001268334,0.0006413691,0.0858868,0.00009979965,0.0002184352,7.7975e-7,0.001241312,0.00004793378,0.9011561,0.0001231207,0.001045625,0.009411883],"study_design_scores_gemma":[0.005266644,0.0007401233,0.04174685,0.0002870273,0.0002250775,2.93094e-7,0.0001811385,0.006999196,0.9430336,0.0001804473,0.0009766637,0.0003629352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963036,0.00003598535,0.0004374427,0.0003344518,0.0001292095,0.001191951,0.0001353811,0.00009143486,0.001340589],"genre_scores_gemma":[0.9932345,0.0002102036,0.003795358,0.0002695831,0.0001165676,0.0002522989,0.0001473834,0.00007594985,0.001898229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04413996,"threshold_uncertainty_score":0.9999157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642971219163267,"score_gpt":0.2661146540811682,"score_spread":0.2396849418895356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}