{"id":"W2806768040","doi":"10.1038/s41598-018-20814-2","title":"Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Vetenskapsrådet; Stockholms Läns Landsting","keywords":"Maraviroc; Tropism; CCR5 receptor antagonist; Tissue tropism; Virology; Genotype; Biology; Co-receptor; Phenotype; Human immunodeficiency virus (HIV); Receptor; Medicine; Gene; Virus; Chemokine receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223475,0.0002889666,0.0002038225,0.0003963361,0.0002902104,0.0003469793,0.0001088849,0.0002377946,0.001169064],"category_scores_gemma":[0.0009861651,0.0001218689,0.0001124549,0.0002996063,0.0002183372,0.0001340358,0.0001500288,0.0002496335,0.0001332686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320211,"about_ca_system_score_gemma":0.00009726369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003868509,"about_ca_topic_score_gemma":0.002365302,"domain_scores_codex":[0.9997721,0.00006154091,0.00001977821,0.00004683942,0.00003447799,0.00006524372],"domain_scores_gemma":[0.9996859,0.0001279254,0.00006536533,0.00003424916,0.00004549166,0.00004112405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001289931,0.0002061893,0.7039499,0.0001148336,0.00008116247,0.004438134,0.001447762,0.0004026349,0.270959,0.0001804892,0.0002925376,0.0166374],"study_design_scores_gemma":[0.00005174982,0.00102584,0.9314224,0.00004078235,0.0000591944,0.02403837,0.001123502,0.001021631,0.03972958,0.00005777609,0.001412439,0.00001671752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995932,0.0001073748,0.00005167913,0.000006744084,0.000001121606,0.000005211956,0.00006038303,0.000001306901,0.0001731324],"genre_scores_gemma":[0.9996539,0.00005682139,0.0001151889,0.000012757,0.000001570067,0.000003326347,0.00008326722,0.000001620586,0.00007160942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003868509,"threshold_uncertainty_score":0.007691979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645805389703673,"score_gpt":0.2474847945139445,"score_spread":0.2310267406169078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}