{"id":"W2806866264","doi":"10.1056/nejmoa1803164","title":"Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":673,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Breast Cancer Research Foundation; Pfizer; Oncosuisse; Ipsen Fund; Ipsen; National Institute for Health and Care Research","keywords":"Exemestane; Tamoxifen; Medicine; Breast cancer; Oncology; Aromatase inhibitor; Internal medicine; Aromatase; Endocrine system; Adjuvant; Gynecology; Adjuvant therapy; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00176575,0.0002912268,0.0007323808,0.0003842899,0.0001030997,0.0003521484,0.0002656317,0.0004023184,0.002078333],"category_scores_gemma":[0.00494827,0.0001152972,0.0005910495,0.0004093624,0.0001896566,0.0002945238,0.0002289736,0.0005328252,0.0003988563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225304,"about_ca_system_score_gemma":0.0004156647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212658,"about_ca_topic_score_gemma":0.001207794,"domain_scores_codex":[0.9992263,0.0004346252,0.00009300462,0.00007829609,0.0001080549,0.00005967209],"domain_scores_gemma":[0.9986268,0.0007548737,0.0003680445,0.00008778273,0.0000514145,0.000110978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1477804,0.003784347,0.1058825,0.001902554,0.002896826,0.0001716423,0.0001867286,0.0137698,0.008950468,0.0004354142,0.002612029,0.7116272],"study_design_scores_gemma":[0.1088532,0.259388,0.5181582,0.001485247,0.01268934,0.00124936,0.000279124,0.03529266,0.01519663,0.01168141,0.03557988,0.0001470134],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675024,0.02175451,0.003726167,0.001311051,0.0002427438,0.0007979923,0.0009004422,0.0001364811,0.003628258],"genre_scores_gemma":[0.9918494,0.004368515,0.001701834,0.0006202044,0.0001884157,0.000307375,0.0004418649,0.000007515281,0.0005149684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002078333,"threshold_uncertainty_score":0.00933826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205600520217908,"score_gpt":0.3093109141611659,"score_spread":0.2887508621393751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}