{"id":"W2806866264","doi":"10.1056/nejmoa1803164","title":"Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":673,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Breast Cancer Research Foundation; Pfizer; Oncosuisse; Ipsen Fund; Ipsen; National Institute for Health and Care Research","keywords":"Exemestane; Tamoxifen; Medicine; Breast cancer; Oncology; Aromatase inhibitor; Internal medicine; Aromatase; Endocrine system; Adjuvant; Gynecology; Adjuvant therapy; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969147,0.0001315451,0.0002412781,0.00004366458,0.00006179215,0.00000447643,0.0001168497,0.00002863385,0.0001042767],"category_scores_gemma":[0.00005126453,0.00008115258,0.00004431442,0.00004713653,0.0001068785,0.000004909978,0.00002290197,0.0000609643,7.448434e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002431282,"about_ca_system_score_gemma":0.0001122219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001557326,"about_ca_topic_score_gemma":0.0001147355,"domain_scores_codex":[0.9992599,0.00002259889,0.0002436448,0.0001299355,0.0001596837,0.0001842527],"domain_scores_gemma":[0.9992555,0.00002564167,0.00017812,0.0001140855,0.0003132792,0.0001133273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007829587,0.000107585,0.03586497,0.00002258409,0.0008538283,0.00002011285,0.0005578018,0.00001271822,0.3088146,0.00005237869,0.0423796,0.6034843],"study_design_scores_gemma":[0.1132134,0.008602248,0.1082009,0.0003440966,0.0002808422,0.001697411,0.0001626455,0.000008163011,0.1071067,0.0003884239,0.6597071,0.0002881066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678191,0.01191704,0.001884717,0.01589581,0.001818653,0.0002217434,0.00003867796,0.000007456284,0.0003968224],"genre_scores_gemma":[0.9732015,0.002427595,0.0004324056,0.0004722561,0.0232148,0.000008511153,0.000007549557,0.00001723415,0.0002181909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6173275,"threshold_uncertainty_score":0.3309306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205600520217908,"score_gpt":0.3093109141611659,"score_spread":0.2887508621393751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}