{"id":"W2806920198","doi":"10.1186/s12885-018-4539-7","title":"ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Shantou University Medical College; Université de Sherbrooke; Shantou University","keywords":"MAPK/ERK pathway; STAT1; MG132; Cancer research; Phosphorylation; Cell biology; Ubiquitin; Transfection; Chemistry; Proteasome inhibitor; Proteasome; Biology; Cell culture; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002789744,0.0001453842,0.0002326107,0.0001015893,0.000125069,0.00003552238,0.0000545484,0.00006850978,0.001222382],"category_scores_gemma":[0.0004150305,0.0001354512,0.00009914353,0.0002227309,0.000062878,0.0001492302,0.00001863134,0.0001353573,0.00001925721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005189212,"about_ca_system_score_gemma":0.0006437149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004158394,"about_ca_topic_score_gemma":0.0004695168,"domain_scores_codex":[0.9988108,0.00003333364,0.0003432996,0.0003270577,0.0001892522,0.0002962911],"domain_scores_gemma":[0.9989908,0.0001864703,0.0001722733,0.0001505549,0.0003828395,0.0001170276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001011657,0.000295448,0.005920754,0.0004796763,0.000114433,0.000002731575,0.01845439,0.00004014824,0.9045485,0.0002852575,0.05335076,0.0154963],"study_design_scores_gemma":[0.002920443,0.0007034124,0.002445461,0.001086776,0.00009020561,0.00000912038,0.001029424,0.01524604,0.9282772,0.0004739112,0.04745524,0.00026278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881852,0.0002355392,0.006664738,0.001611413,0.0004155734,0.001163562,0.0002754463,0.00007617599,0.001372404],"genre_scores_gemma":[0.9908032,0.000006831554,0.003615801,0.0009416312,0.0009082219,0.0002940721,0.00004049603,0.00004212399,0.003347629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02372874,"threshold_uncertainty_score":0.9996907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03893278743835989,"score_gpt":0.3479108314355362,"score_spread":0.3089780439971764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}