{"id":"W2806927747","doi":"10.1038/s41598-018-20837-9","title":"p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université Laval","keywords":"p38 mitogen-activated protein kinases; microRNA; Leukocyte extravasation; Cancer research; Extravasation; Cell biology; Transcription factor; Kinase; E-selectin; Cancer cell; Cell adhesion molecule; Biology; Cell adhesion; MAPK/ERK pathway; Cancer; Immunology; Cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164989,0.0003614434,0.0002366364,0.0001940431,0.0001716439,0.0001951383,0.0001250976,0.0001599339,0.001920435],"category_scores_gemma":[0.0001435354,0.0001645296,0.0003002131,0.0001179518,0.0001849219,0.0001813271,0.0002028983,0.0005422744,0.0004313228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547274,"about_ca_system_score_gemma":0.0002667855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002611654,"about_ca_topic_score_gemma":0.0004077728,"domain_scores_codex":[0.9998324,0.00002757516,0.00001587335,0.00003331358,0.00004710705,0.00004371014],"domain_scores_gemma":[0.9999348,0.00001005975,0.00002128504,0.000008671155,0.000007783633,0.0000174432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001752885,0.00005334879,0.00009428784,0.00005458044,0.00000435424,0.00006710564,0.00001964939,0.00004808477,0.9980232,0.00009240931,0.00004600401,0.001321791],"study_design_scores_gemma":[0.00003333131,0.0004408885,0.002284511,0.000004640452,0.000009192625,0.0003292654,0.00001846264,0.0009101703,0.992623,0.00006353785,0.003279459,0.000003529455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870185,0.003542226,0.005444022,0.000171705,0.00009602889,0.0000922881,0.0003338968,0.0001286465,0.003172747],"genre_scores_gemma":[0.9923003,0.00121786,0.003013419,0.00006142159,0.00001845032,0.00009268423,0.0003331003,0.00001732013,0.002945497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001920435,"threshold_uncertainty_score":0.006424487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580206532518125,"score_gpt":0.317409197883775,"score_spread":0.2916071325585937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}