{"id":"W2807016784","doi":"10.1158/1078-0432.ccr-18-0481","title":"Phase I Trials of Anti-ENPP3 Antibody–Drug Conjugates in Advanced Refractory Renal Cell Carcinomas","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; BC Cancer Agency; London Health Sciences Centre; Alberta Cancer Foundation","funders":"National Cancer Institute","keywords":"Medicine; Pharmacokinetics; Toxicity; Refractory (planetary science); Renal cell carcinoma; Pharmacology; Internal medicine; Gastroenterology; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001400382,0.0009820177,0.001819034,0.0002732646,0.0003631837,0.0005986945,0.0007346293,0.0008474673,0.00159346],"category_scores_gemma":[0.0007310824,0.0003998467,0.0006158451,0.0003240275,0.0005675061,0.0005116236,0.0002109913,0.001977463,0.000370675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001058117,"about_ca_system_score_gemma":0.001220884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009990466,"about_ca_topic_score_gemma":0.002058994,"domain_scores_codex":[0.9995726,0.0002068803,0.00002995647,0.00006670116,0.00004987551,0.00007399295],"domain_scores_gemma":[0.9994695,0.0001080397,0.0001262982,0.0000577902,0.000058324,0.00018002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3672886,0.07538027,0.008724768,0.001247104,0.001474196,0.0006374179,0.0006852911,0.007447222,0.4068137,0.0004540769,0.002698345,0.1271491],"study_design_scores_gemma":[0.208908,0.715788,0.0123923,0.00003524722,0.0004395794,0.0006005639,0.0000783358,0.002748146,0.05476648,0.0001698467,0.004040879,0.00003265136],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967811,0.001417093,0.0004120894,0.00008258892,0.00003696636,0.0006302989,0.0001323392,0.00003610597,0.0004714236],"genre_scores_gemma":[0.9965631,0.0006219194,0.0008177732,0.0001370421,0.00005922481,0.0005487378,0.0004031096,0.00001412322,0.0008348736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001819034,"threshold_uncertainty_score":0.007677197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2753566075983032,"score_gpt":0.5755549612296069,"score_spread":0.3001983536313037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}