{"id":"W2807016784","doi":"10.1158/1078-0432.ccr-18-0481","title":"Phase I Trials of Anti-ENPP3 Antibody–Drug Conjugates in Advanced Refractory Renal Cell Carcinomas","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; BC Cancer Agency; London Health Sciences Centre; Alberta Cancer Foundation","funders":"National Cancer Institute","keywords":"Medicine; Pharmacokinetics; Toxicity; Refractory (planetary science); Renal cell carcinoma; Pharmacology; Internal medicine; Gastroenterology; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01088015,0.0002079395,0.001396203,0.0003818114,0.0001267613,0.0000244221,0.0002938669,0.0002176144,0.001559319],"category_scores_gemma":[0.004701436,0.000169071,0.0003658087,0.0007625138,0.001256561,0.0001582912,0.0001405086,0.0008168453,0.00007267085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116627,"about_ca_system_score_gemma":0.00123922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273235,"about_ca_topic_score_gemma":0.0003085791,"domain_scores_codex":[0.9944919,0.001189112,0.002072427,0.0006672507,0.0009038614,0.0006754803],"domain_scores_gemma":[0.9939104,0.00365615,0.0004189098,0.0006547317,0.0009673721,0.0003924788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01369582,0.005278954,0.5363284,0.0006104286,0.0001840791,0.0001677593,0.001238918,0.000007140164,0.3540503,0.0002528318,0.01562095,0.07256442],"study_design_scores_gemma":[0.04660604,0.008449414,0.4589432,0.001817038,0.0001834669,0.000008292988,0.0006124161,0.0006425108,0.3902257,0.000914371,0.09105293,0.0005446625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864957,0.008725662,0.00001443318,0.001261338,0.000521725,0.0008644462,0.0000731608,0.00003330249,0.00201019],"genre_scores_gemma":[0.9919513,0.003517489,0.0001994772,0.0002160121,0.001662359,0.00004306938,0.00005976219,0.00004127671,0.002309287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07738528,"threshold_uncertainty_score":0.9993534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2753566075983032,"score_gpt":0.5755549612296069,"score_spread":0.3001983536313037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}