{"id":"W2807141429","doi":"10.1038/s41598-018-20052-6","title":"Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Children’s Hospital of Wisconsin Research Institute; Midwest Athletes Against Childhood Cancer; University Health Network; University of South Carolina; Medical University of South Carolina","keywords":"Pathogenesis; Medicine; Microbiology; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100534,0.0000902718,0.0001492451,0.00006587854,0.0001117389,0.00002246763,0.000111326,0.00007449184,0.00004582581],"category_scores_gemma":[0.0002755414,0.00008015522,0.0001031854,0.0002391647,0.0003707273,0.000005543116,0.00007419646,0.00002215273,0.000002460335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003721298,"about_ca_system_score_gemma":0.0001153499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001923966,"about_ca_topic_score_gemma":0.000007505687,"domain_scores_codex":[0.9986731,0.00003635954,0.0004447044,0.0004147805,0.0002538087,0.000177265],"domain_scores_gemma":[0.9986069,0.000003631916,0.0003434078,0.0006058891,0.0003852985,0.00005492041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001401587,0.00004197031,0.004395916,0.00002343729,0.000006558473,0.000004190988,0.00009371756,0.00001195822,0.992392,0.00005510353,0.0006379753,0.002323173],"study_design_scores_gemma":[0.00008237299,0.00007091939,0.002467517,0.000013574,0.00001908939,0.0000399501,0.00005858605,0.00001963441,0.991133,0.0004931256,0.005516971,0.00008519887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939362,0.0009197454,0.002531206,0.000007387629,0.001801533,0.00009315732,0.000006406333,0.000006768616,0.0006976073],"genre_scores_gemma":[0.9980421,0.00001708892,0.001392133,0.00001311163,0.000202684,0.000004025754,0.00005083016,0.000009263541,0.0002687699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004878995,"threshold_uncertainty_score":0.3268635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00934086385296377,"score_gpt":0.2436633882052988,"score_spread":0.234322524352335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}