{"id":"W2807183065","doi":"10.1016/j.mrgentox.2018.05.021","title":"Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing","year":2018,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Health and Environmental Sciences Institute","keywords":"Somatic cell; Germ cell; Biology; Sperm; Germ; Germline; Transgene; Cell; Andrology; Azoospermia; Genetics; Cell biology; Gene; Medicine; Infertility","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00773212,0.001978822,0.001330937,0.005832571,0.001047658,0.001234288,0.002149462,0.001708016,0.005330595],"category_scores_gemma":[0.004892012,0.000922178,0.002686628,0.002379315,0.001188741,0.0007437436,0.001326578,0.001574124,0.003101569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000981797,"about_ca_system_score_gemma":0.003076892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004563524,"about_ca_topic_score_gemma":0.01787737,"domain_scores_codex":[0.9855098,0.003559435,0.00186769,0.001332614,0.007062151,0.000668208],"domain_scores_gemma":[0.9919056,0.001476029,0.001552351,0.001481133,0.003311353,0.0002736204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003050807,0.0002658538,0.006947058,0.001020506,0.0001356233,0.0003886602,0.0002556984,0.0008254269,0.9583856,0.001193591,0.002739621,0.02753736],"study_design_scores_gemma":[0.00005081021,0.002016087,0.01901137,0.0002238513,0.0004125194,0.0008836088,0.0001436559,0.00121077,0.9269592,0.0006167109,0.0483635,0.0001079594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2990944,0.007921518,0.6082546,0.00102673,0.0008075722,0.01033352,0.03048645,0.005027687,0.03704762],"genre_scores_gemma":[0.3188253,0.01793933,0.5410324,0.001345184,0.0001213042,0.01401243,0.06327094,0.001929217,0.04152396],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00773212,"threshold_uncertainty_score":0.04089189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03249225193404614,"score_gpt":0.3011116776078717,"score_spread":0.2686194256738255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}