{"id":"W2807183065","doi":"10.1016/j.mrgentox.2018.05.021","title":"Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing","year":2018,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Health and Environmental Sciences Institute","keywords":"Somatic cell; Germ cell; Biology; Sperm; Germ; Germline; Transgene; Cell; Andrology; Azoospermia; Genetics; Cell biology; Gene; Medicine; Infertility","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008750889,0.000399776,0.0003229294,0.0002550564,0.0008103979,0.0001637326,0.0001539159,0.0002614774,0.0001005669],"category_scores_gemma":[0.00007409808,0.0003852075,0.0000538495,0.0001757762,0.0007022106,0.00003627963,0.0002451122,0.0002182148,0.0000163839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282185,"about_ca_system_score_gemma":0.0001247231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001356719,"about_ca_topic_score_gemma":0.0002301468,"domain_scores_codex":[0.9969115,0.000436244,0.0006464973,0.0009211296,0.0004722033,0.0006124686],"domain_scores_gemma":[0.998766,0.0002279342,0.0002853883,0.0003600163,0.00009136418,0.0002692745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008030113,0.0002998121,0.0223906,0.000157667,0.00004137258,0.00005362632,0.0006513176,0.0006469734,0.9700073,9.990825e-7,0.00001614006,0.005653911],"study_design_scores_gemma":[0.001558091,0.002443494,0.110359,0.0000296314,0.0001740549,0.0003173613,0.002253602,0.01803415,0.8642632,0.0000932681,0.00003824295,0.0004358957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778231,0.001472594,0.0194375,0.00007057424,0.00006826064,0.0009194505,0.00007309944,0.0000200188,0.0001154173],"genre_scores_gemma":[0.9738483,0.0004378377,0.02483884,0.0001335152,0.0001620215,0.00009495715,0.0001987074,0.000067608,0.0002182232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1057441,"threshold_uncertainty_score":0.99986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03249225193404614,"score_gpt":0.3011116776078717,"score_spread":0.2686194256738255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}