{"id":"W2807186038","doi":"10.1038/s41395-018-0098-4","title":"Open : Lymphoma Risk and Overall Safety Profile of Adalimumab in Patients With Crohn's Disease With up to 6 Years of Follow-up in the PYRAMID Registry","year":2018,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Medicine; Adalimumab; Internal medicine; Population; Lymphoma; Prospective cohort study; Rate ratio; Epidemiology; Crohn's disease; Adverse effect; Surgery; Gastroenterology; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002935255,0.000162075,0.0003637511,0.0006365479,0.000261364,0.0007770149,0.0004642604,0.0002863166,0.002923226],"category_scores_gemma":[0.005835381,0.0001970089,0.0006504547,0.001155293,0.0002188497,0.001070767,0.0009200295,0.000382472,0.0005400626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897395,"about_ca_system_score_gemma":0.0006285273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001612541,"about_ca_topic_score_gemma":0.002132526,"domain_scores_codex":[0.9985039,0.0003552679,0.0001921798,0.0003569605,0.0004756332,0.0001159567],"domain_scores_gemma":[0.9938221,0.0007584795,0.003672966,0.0008867334,0.0005318898,0.0003277272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001619816,0.00006741669,0.9875668,0.00004507632,0.0001649652,0.00007954809,0.00005211222,0.00009646326,0.0003070073,0.00003165149,0.0007555076,0.0092136],"study_design_scores_gemma":[0.0001898331,0.0008439568,0.9964944,0.00001259614,0.0002055542,0.000446484,0.00006553499,0.0004384115,0.000218412,0.00004317176,0.001034977,0.000006662039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943711,0.0002979552,0.0003631596,0.0000688397,0.000005587959,0.00004545751,0.003784776,0.00003292675,0.001030177],"genre_scores_gemma":[0.9947317,0.000120008,0.0003061252,0.00004757668,0.00002392237,0.00003441761,0.004443643,0.00000696273,0.000285721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002935255,"threshold_uncertainty_score":0.01552331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003663595671881334,"score_gpt":0.2164157772426347,"score_spread":0.2127521815707534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}