{"id":"W2807192583","doi":"10.1186/s13000-018-0696-x","title":"Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer","year":2018,"lang":"en","type":"article","venue":"Diagnostic Pathology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Magnification; Immunohistochemistry; Pathology; Breast cancer; Biopsy; Cancer; Medicine; Intensity (physics); Nuclear medicine; Internal medicine; Physics; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111328,0.0000798059,0.0003125541,0.00008182291,0.00002602297,0.000002063711,0.0001029798,0.00006639016,0.00002802226],"category_scores_gemma":[0.001905428,0.0000602961,0.0000547286,0.0002393992,0.0005711023,0.00001780341,0.00006285817,0.0001382322,0.000001135415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001170947,"about_ca_system_score_gemma":0.0002179454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798816,"about_ca_topic_score_gemma":0.00002018817,"domain_scores_codex":[0.9991009,0.00007713406,0.0002333868,0.0002039806,0.0001789451,0.0002056303],"domain_scores_gemma":[0.9985089,0.0008608427,0.00009115764,0.0002658294,0.0002294253,0.00004383461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006478637,0.0002810379,0.4045714,0.0004197661,0.00002568706,0.00001068163,0.0009637235,0.000002211059,0.5592647,0.000218342,0.0003441497,0.03325052],"study_design_scores_gemma":[0.002266226,0.0003668076,0.8051299,0.0004209467,0.00007886707,0.0000836282,0.00008629973,0.0001676147,0.1907994,0.0004259759,0.0001055319,0.00006874387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997277,0.0004546686,0.00028399,0.001042754,0.0001089028,0.0005524126,0.0001425604,0.000006109395,0.0001316298],"genre_scores_gemma":[0.9988633,0.0002068067,0.0004791746,0.00004821114,0.0001412202,0.0002284822,0.000005356933,0.00001334944,0.0000140938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4005586,"threshold_uncertainty_score":0.2458804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02379823563574092,"score_gpt":0.3652826096877164,"score_spread":0.3414843740519755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}