{"id":"W2807244885","doi":"10.1128/aac.02576-17","title":"Iron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator DIBI Inhibits Growth and Increases Sensitivity to Azoles<i>In Vitro</i>and<i>In Vivo</i>in a Murine Model of Experimental Vaginitis","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Nova Scotia Health Authority; Dalhousie University","funders":"National Institute of General Medical Sciences; Government of Canada","keywords":"In vivo; Candida albicans; In vitro; Microbiology; Biology; Pharmacology; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363963,0.0003151579,0.0002835282,0.0002065479,0.0001417386,0.0001734993,0.0002767127,0.0002383162,0.0008367877],"category_scores_gemma":[0.0001231681,0.0001006365,0.0001239559,0.00009473911,0.0001428171,0.00009927117,0.00009042971,0.000461937,0.0001813756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623578,"about_ca_system_score_gemma":0.0001729015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009499327,"about_ca_topic_score_gemma":0.001336259,"domain_scores_codex":[0.9998999,0.00002629143,0.00000923763,0.00001711984,0.00002383793,0.00002374191],"domain_scores_gemma":[0.9999346,0.00001536904,0.00001513019,0.000007456532,0.0000107223,0.00001676923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003794161,0.0002229416,0.000135422,0.00003581301,0.000004816379,0.00002750982,0.00001054966,0.00003967176,0.9970284,0.0000302248,0.00007319765,0.002011984],"study_design_scores_gemma":[0.00006058193,0.002342065,0.002885365,0.000007478176,0.000015776,0.0001621269,0.00001169659,0.0008316442,0.9924088,0.00001510449,0.001255869,0.000003600748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944661,0.002569373,0.001370207,0.0001514042,0.00003812844,0.00004580875,0.0001111856,0.00006500159,0.001182765],"genre_scores_gemma":[0.9937919,0.001384121,0.002731877,0.00008312242,0.00002246739,0.00003916892,0.0002728525,0.00001156822,0.001662932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009499327,"threshold_uncertainty_score":0.002799332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784080780275104,"score_gpt":0.2925158843445998,"score_spread":0.2746750765418488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}