{"id":"W2807256072","doi":"10.1038/s41540-018-0051-6","title":"Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects","year":2018,"lang":"en","type":"article","venue":"npj Systems Biology and Applications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Science and Technology Agency; Ono Medical Research Foundation; Japan Society for the Promotion of Science; Core Research for Evolutional Science and Technology; Japan Diabetes Foundation","keywords":"Insulin; Internal medicine; Endocrinology; Peripheral; Diabetes mellitus; Medicine; Pathogenesis; Type 2 diabetes","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287406,0.0002241053,0.0002523799,0.0002003674,0.00008338512,0.0004132483,0.0002015776,0.0002302104,0.0003561267],"category_scores_gemma":[0.0004780438,0.0001330573,0.0003908154,0.0001536129,0.000280949,0.0002326551,0.0002109241,0.0002428832,0.0000580545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498328,"about_ca_system_score_gemma":0.0002410702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002017784,"about_ca_topic_score_gemma":0.001090189,"domain_scores_codex":[0.9999233,0.00002487435,0.000005409117,0.00002115635,0.00001251818,0.00001271929],"domain_scores_gemma":[0.9998949,0.00004089565,0.00004083104,0.000009697168,0.000006860189,0.000006772052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.001315404,0.0004461573,0.1361199,0.0002635189,0.0003953283,0.001571131,0.0002328224,0.6783122,0.1191462,0.0228056,0.0006695153,0.0387222],"study_design_scores_gemma":[0.00003395464,0.0002247539,0.03013974,0.0000118602,0.00007898208,0.0005393234,0.00004224374,0.9548872,0.005801146,0.007564317,0.0006547289,0.00002179446],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8528388,0.0008150126,0.1439171,0.0002454685,0.0000214992,0.00002253823,0.0001123437,0.00009596819,0.00193122],"genre_scores_gemma":[0.9933711,0.0002625328,0.005726967,0.0000232692,0.000006293098,0.00001662136,0.00005465278,0.000007286127,0.0005313903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017784,"threshold_uncertainty_score":0.004012108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084786092249898,"score_gpt":0.2530550999787172,"score_spread":0.2422072390562182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}