{"id":"W2807268675","doi":"10.1186/s40478-018-0548-7","title":"Proteomic analysis of Medulloblastoma reveals functional biology with translational potential","year":2018,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Intellectual and Developmental Disabilities Research Center; Oregon Health and Science University; Prevent Cancer Foundation","keywords":"Stable isotope labeling by amino acids in cell culture; Biology; Proteomics; Medulloblastoma; Proteome; Computational biology; Quantitative proteomics; Druggability; Genomics; Phenotype; Phosphoproteomics; Genetics; Genome; Gene; Phosphorylation; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003460835,0.0002775701,0.0001895912,0.000582504,0.000231091,0.0004274907,0.0001389766,0.000176594,0.0004423579],"category_scores_gemma":[0.0003674569,0.0001469211,0.0002118351,0.0004886877,0.000302657,0.0002913448,0.0001471093,0.0002467028,0.000132769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005292285,"about_ca_system_score_gemma":0.000365495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002533424,"about_ca_topic_score_gemma":0.003503499,"domain_scores_codex":[0.9998747,0.00002150469,0.00001162224,0.00002751756,0.00004647485,0.00001806356],"domain_scores_gemma":[0.9998782,0.00002690391,0.00003597351,0.00001624532,0.00002190554,0.00002072749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001451786,0.000007086455,0.004085182,0.00004502984,0.00001275746,0.00004852931,0.00002452067,0.00009996826,0.9933459,0.0001221598,0.00002948944,0.002034223],"study_design_scores_gemma":[0.0000157246,0.0003966678,0.3004325,0.00001765999,0.00009701814,0.001094354,0.0003086538,0.003293964,0.6896618,0.0007138781,0.003953,0.00001486071],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994242,0.001577482,0.002878416,0.0001037123,0.000005836961,0.00001207158,0.0004620134,0.00005117069,0.0006672911],"genre_scores_gemma":[0.9934102,0.001033166,0.004350815,0.00003091595,0.000005059527,0.00001166623,0.0006150859,0.00001343893,0.0005297039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002533424,"threshold_uncertainty_score":0.005037367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050912155917195,"score_gpt":0.2671781489149338,"score_spread":0.2466690273557618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}