{"id":"W2807294662","doi":"10.1016/j.atherosclerosissup.2018.04.042","title":"The APPROACH Study: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Volanesorsen Administered Subcutaneously to Patients with FCS","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Université du Québec à Chicoutimi","funders":"Ionis Pharmaceuticals","keywords":"Medicine; Adverse effect; Dermatomyositis; Polymyositis; Lipoatrophy; Myositis; Placebo; Inclusion body myositis; Surgery; Internal medicine; Physical therapy; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102301,0.00156652,0.003296305,0.0007343909,0.0005780947,0.0008973295,0.0008710594,0.001667926,0.006346799],"category_scores_gemma":[0.0009544225,0.0005740886,0.00161716,0.0004318455,0.001260524,0.0009763523,0.0004279483,0.002838267,0.0008269366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004199196,"about_ca_system_score_gemma":0.001474203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198934,"about_ca_topic_score_gemma":0.002595524,"domain_scores_codex":[0.9996136,0.0001749104,0.00002524792,0.00006145649,0.0000411077,0.00008375989],"domain_scores_gemma":[0.9994586,0.0001493605,0.0001142203,0.00003878443,0.00002910782,0.0002098767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9663509,0.0119853,0.0003793059,0.000596326,0.0005469145,0.00004527458,0.00007456022,0.000273742,0.006411918,0.0001770695,0.0004336949,0.0127249],"study_design_scores_gemma":[0.9242252,0.07371067,0.0008792081,0.00001831562,0.0001816196,0.00001646258,0.000022958,0.0001599405,0.0003640149,0.0000672145,0.0003439038,0.00001048406],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879562,0.003082392,0.001056079,0.0004783114,0.0003265244,0.003945622,0.000829621,0.0001925927,0.002132651],"genre_scores_gemma":[0.9790859,0.003645838,0.002988137,0.00146598,0.0005554362,0.006379234,0.001067265,0.00004660804,0.004765589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006346799,"threshold_uncertainty_score":0.02123213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02685192544152251,"score_gpt":0.3035840291559008,"score_spread":0.2767321037143783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}