{"id":"W2807294662","doi":"10.1016/j.atherosclerosissup.2018.04.042","title":"The APPROACH Study: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Volanesorsen Administered Subcutaneously to Patients with FCS","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Université du Québec à Chicoutimi","funders":"Ionis Pharmaceuticals","keywords":"Medicine; Adverse effect; Dermatomyositis; Polymyositis; Lipoatrophy; Myositis; Placebo; Inclusion body myositis; Surgery; Internal medicine; Physical therapy; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001242294,0.00051071,0.001594153,0.0001785575,0.0006082075,0.0001333681,0.000420468,0.00008876781,0.0001902856],"category_scores_gemma":[0.00008640396,0.000295113,0.0002216705,0.0003974091,0.0002401605,0.0001135565,0.0002012341,0.0002043488,0.00005926678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000834042,"about_ca_system_score_gemma":0.0000927495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194837,"about_ca_topic_score_gemma":0.0005179094,"domain_scores_codex":[0.9955873,0.0004835973,0.001337965,0.0006493987,0.001275031,0.0006667],"domain_scores_gemma":[0.9971282,0.0002779812,0.0005426917,0.001127086,0.0006217304,0.0003022616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.853022,0.009775861,0.1224969,0.00003246674,0.001428917,0.00001821613,0.0119468,0.000002539757,0.00009873699,0.00001569855,0.0007884991,0.000373389],"study_design_scores_gemma":[0.9657071,0.01618395,0.006660315,0.00006998328,0.001188417,0.00001691717,0.008771576,0.0001222985,0.0002067162,0.000002484625,0.0007360411,0.0003341555],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755809,0.00001412417,0.0001021505,0.00009831131,0.0002013928,0.02328996,0.00007555254,0.00006665575,0.0005709982],"genre_scores_gemma":[0.9961246,0.000007017333,0.0002902027,0.0002091425,0.0001626611,0.002694366,0.00009008404,0.00009171828,0.0003302706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1158366,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02685192544152251,"score_gpt":0.3035840291559008,"score_spread":0.2767321037143783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}