{"id":"W2807295499","doi":"10.1038/s41588-018-0133-9","title":"Multi-ethnic genome-wide association study for atrial fibrillation","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":810,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; University of Alberta; McMaster University; Population Health Research Institute","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Medical Research Council; Biosense Webster; National Institutes of Health; Doris Duke Charitable Foundation; Novo Nordisk Fonden; Yale University; Fondation Leducq; Broad Institute; European Commission; Quest Diagnostics; Amarin Corporation; Bristol-Myers Squibb; St. Jude Medical; Regeneron Pharmaceuticals; British Heart Foundation","keywords":"Biology; Genome-wide association study; Atrial fibrillation; Ethnic group; Genetics; Genetic association; Association (psychology); Computational biology; Evolutionary biology; Internal medicine; Gene; Single-nucleotide polymorphism; Genotype; Anthropology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001329007,0.001002748,0.001966208,0.002127075,0.0002533,0.0006407987,0.001015781,0.001568407,0.004303603],"category_scores_gemma":[0.002062894,0.0002432201,0.0008288788,0.002532386,0.0004732573,0.0005803235,0.000649657,0.001783157,0.002017392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004889554,"about_ca_system_score_gemma":0.00114874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00145657,"about_ca_topic_score_gemma":0.00229386,"domain_scores_codex":[0.9994462,0.000126417,0.00008688937,0.0001227189,0.0001746484,0.00004312861],"domain_scores_gemma":[0.9987689,0.0006132017,0.000194542,0.00004164988,0.0002662796,0.0001154597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001815759,0.0000513909,0.00293681,0.009625774,0.000738698,0.0002538219,0.00004138663,0.0001577386,0.0004178523,0.002101261,0.04080531,0.9426884],"study_design_scores_gemma":[0.00017716,0.0002404376,0.02866339,0.0135736,0.002189862,0.00520299,0.00008526859,0.0002380869,0.0005402541,0.005022123,0.9439833,0.00008358315],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0001510266,0.9979032,0.0001802384,0.0007129332,0.000313198,0.00000675212,0.00005671437,0.000008572875,0.0006673186],"genre_scores_gemma":[0.001746727,0.9965654,0.0002410197,0.0004865027,0.0003956256,0.00001551233,0.0001178018,0.000003166054,0.0004281533],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004303603,"threshold_uncertainty_score":0.01439697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04551355418812808,"score_gpt":0.3765784192778404,"score_spread":0.3310648650897123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}