{"id":"W2807314079","doi":"10.1038/s41598-018-25559-6","title":"Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hepatitis C virus research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; University of Alberta","funders":"Center for AIDS Research, University of Washington; National Institute of Allergy and Infectious Diseases; Medical Research Council; Murdoch University; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Raine Medical Research Foundation; National Institute for Health and Care Research; Vanderbilt University; Wellcome Trust; Australian Centre for HIV and Hepatitis Virology Research; National Science Foundation","keywords":"Human leukocyte antigen; Biology; Genotype; Virology; Hepatitis C virus; Immunology; Immune system; Epitope; CD8; T cell; Context (archaeology); Virus; Genetics; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030493,0.0001051817,0.0001305873,0.0002443087,0.0001697665,0.000286401,0.000178829,0.0001968281,0.003183932],"category_scores_gemma":[0.0006730994,0.00007496837,0.0001207575,0.0002879858,0.0003387299,0.0001323658,0.0002502447,0.0002993968,0.0002622508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001068432,"about_ca_system_score_gemma":0.0001483052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046296,"about_ca_topic_score_gemma":0.0009153595,"domain_scores_codex":[0.9998001,0.00004585426,0.00001211944,0.00005003547,0.00004976545,0.00004202057],"domain_scores_gemma":[0.9991315,0.0002616068,0.0002162586,0.0001324614,0.0001119183,0.000146137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001467131,0.0001303823,0.7186029,0.0001055984,0.0001604961,0.0007641364,0.000347075,0.0002535971,0.2543554,0.000317261,0.0003787426,0.02311726],"study_design_scores_gemma":[0.00001933375,0.0002888697,0.9868319,0.00001488053,0.0000360889,0.001132448,0.0002484564,0.0003829045,0.009962196,0.000208413,0.0008707916,0.000003764996],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985443,0.0002266156,0.0003195429,0.00004775698,0.00000436144,0.000002203237,0.00008742694,0.00000471327,0.0007630351],"genre_scores_gemma":[0.9994973,0.00006902863,0.0001131144,0.00002952021,0.000006543316,0.000002598124,0.00007264377,0.000001405944,0.00020775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183932,"threshold_uncertainty_score":0.01065129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05026960913103583,"score_gpt":0.3172982135389375,"score_spread":0.2670286044079017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}