{"id":"W2807340459","doi":"10.1074/jbc.ra118.004542","title":"A functional study of all 40 Caenorhabditis elegans insulin-like peptides","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Caenorhabditis elegans; Insulin; Gene; Biology; Genome; Genetics; Caenorhabditis; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254843,0.0006165342,0.0002555694,0.0002858508,0.0004356854,0.0003926713,0.0003145948,0.0004417609,0.001673445],"category_scores_gemma":[0.0001948217,0.0001155529,0.0004651102,0.0001791439,0.0002786517,0.0005587935,0.0001751843,0.0007094168,0.0004541419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493165,"about_ca_system_score_gemma":0.000398234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420001,"about_ca_topic_score_gemma":0.001377506,"domain_scores_codex":[0.9999297,0.000004969789,0.000006693892,0.00002410828,0.00001574964,0.00001883656],"domain_scores_gemma":[0.9997821,0.00002844513,0.00003052177,0.00002058627,0.00004175907,0.00009661714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002585817,0.00003187419,0.0004737929,0.00003562398,0.000007763332,0.00009801739,0.00001367664,0.00005850653,0.9963533,0.0001935918,0.00007981999,0.002395541],"study_design_scores_gemma":[0.0001082033,0.0009071738,0.04352643,0.00003558031,0.0001183231,0.001481869,0.0001568283,0.001593714,0.9344327,0.0005956419,0.01700964,0.00003404918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885877,0.002663835,0.003364427,0.0003139508,0.0001517773,0.00007527845,0.001467432,0.00005389229,0.003321685],"genre_scores_gemma":[0.9745258,0.002068659,0.01300244,0.000368153,0.00004617557,0.00009272519,0.004142356,0.00004281059,0.005711092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673445,"threshold_uncertainty_score":0.005598187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780232626720124,"score_gpt":0.2533352269290958,"score_spread":0.2255329006618946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}