{"id":"W2807342171","doi":"10.1002/cpdd.471","title":"Pharmacokinetic Characteristics of Tofacitinib in Adult Patients With Moderate to Severe Chronic Plaque Psoriasis","year":2018,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Probity Medical Research","funders":"Pfizer","keywords":"Janus kinase inhibitor; Medicine; Tofacitinib; Dosing; Pharmacokinetics; Psoriasis; Volume of distribution; Renal function; Plaque psoriasis; Internal medicine; Body surface area; Creatinine; Body mass index; Clearance; Gastroenterology; Pharmacology; Urology; Immunology; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006154249,0.0002164636,0.0005757896,0.0002186549,0.0001577736,0.0003443727,0.00008373477,0.0002673112,0.0007625463],"category_scores_gemma":[0.002013792,0.000132828,0.000382193,0.0003048338,0.00008874432,0.0002730174,0.000106993,0.0003595323,0.0001735956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624184,"about_ca_system_score_gemma":0.0002542912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011721,"about_ca_topic_score_gemma":0.0008720467,"domain_scores_codex":[0.9997635,0.00007768705,0.00002587397,0.00005347149,0.00005543356,0.00002398489],"domain_scores_gemma":[0.9993609,0.0003100953,0.0001758443,0.00004166273,0.00004612985,0.00006539433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007788235,0.0004915036,0.9158036,0.0001276509,0.000615878,0.0009999147,0.0003004207,0.005783884,0.009661449,0.0001887206,0.001110465,0.05712822],"study_design_scores_gemma":[0.0005483956,0.004660387,0.9742508,0.00002447579,0.0003195334,0.003601722,0.0001568921,0.01239374,0.00120972,0.0003753952,0.002431222,0.000027681],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978248,0.0007506157,0.0006493528,0.00003810439,0.000003370248,0.00001957488,0.000297587,0.00001481382,0.0004018506],"genre_scores_gemma":[0.9991459,0.0001866967,0.0002528469,0.00003600624,0.0000101564,0.00001122853,0.0002592492,0.000002107367,0.00009591212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011721,"threshold_uncertainty_score":0.003254652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935625667845373,"score_gpt":0.303296412492652,"score_spread":0.2839401558141982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}