{"id":"W2807348997","doi":"10.1101/344234","title":"Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; University of Prince Edward Island; SickKids Foundation; University of Toronto; McMaster University; Hospital for Sick Children","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics; National Institutes of Health; Hospital for Sick Children; Sick Kids Foundation; Genome Canada; Canadian Institute for Advanced Research; Autism Speaks; University of Toronto; National Alliance for Research on Schizophrenia and Depression; GlaxoSmithKline; International Rett Syndrome Foundation","keywords":"Biology; Gene; Induced pluripotent stem cell; Candidate gene; CRISPR; Phenotype; Genetics; Excitatory postsynaptic potential; Neuroscience; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130634,0.0003455711,0.0002209362,0.0002582737,0.00009340859,0.000240962,0.0002008469,0.0002174256,0.001987322],"category_scores_gemma":[0.0001638312,0.0001000371,0.0002077476,0.0001087513,0.0001936448,0.00009659321,0.0002948843,0.0003625242,0.0004521003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162329,"about_ca_system_score_gemma":0.0001074863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003128681,"about_ca_topic_score_gemma":0.0004074016,"domain_scores_codex":[0.999844,0.00001797504,0.00001911991,0.00005493278,0.00004704833,0.00001698194],"domain_scores_gemma":[0.9999166,0.00001870677,0.00001948606,0.00001785983,0.00000761352,0.00001984584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003925484,0.00001384479,0.0003642307,0.00001729167,0.00001156548,0.000126038,0.00001351372,0.0001498191,0.9970514,0.0001303278,0.00007348198,0.00200937],"study_design_scores_gemma":[0.00001609652,0.0001421606,0.01085486,0.000008373166,0.00004214391,0.001591989,0.00003500123,0.001882798,0.9806908,0.0002741033,0.004456257,0.000005513757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885269,0.0003428557,0.00831155,0.00007341541,0.00002849901,0.00001738624,0.0006817206,0.0002171879,0.0018004],"genre_scores_gemma":[0.9937357,0.000253751,0.002796639,0.00003921444,0.000005613795,0.00002646763,0.001053357,0.00006458817,0.002024668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987322,"threshold_uncertainty_score":0.006648183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503413753029364,"score_gpt":0.2601749794701433,"score_spread":0.2451408419398497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}