{"id":"W2807348997","doi":"10.1101/344234","title":"Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; University of Prince Edward Island; SickKids Foundation; University of Toronto; McMaster University; Hospital for Sick Children","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics; National Institutes of Health; Hospital for Sick Children; Sick Kids Foundation; Genome Canada; Canadian Institute for Advanced Research; Autism Speaks; University of Toronto; National Alliance for Research on Schizophrenia and Depression; GlaxoSmithKline; International Rett Syndrome Foundation","keywords":"Biology; Gene; Induced pluripotent stem cell; Candidate gene; CRISPR; Phenotype; Genetics; Excitatory postsynaptic potential; Neuroscience; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005135479,0.0004418767,0.0005397132,0.0001070957,0.0001356251,0.00003070838,0.0003786175,0.0004670769,0.0000304404],"category_scores_gemma":[0.0001608889,0.0005101145,0.0002608602,0.0001550203,0.0003407263,0.000009223908,0.0005133991,0.0002702803,0.00000252529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005202072,"about_ca_system_score_gemma":0.0002041438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005542538,"about_ca_topic_score_gemma":0.00001111211,"domain_scores_codex":[0.9975339,0.0001458134,0.0006840707,0.0009715256,0.0002881973,0.0003765183],"domain_scores_gemma":[0.9978352,0.00002904858,0.0005724567,0.001028903,0.0003968025,0.0001376074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004706733,0.0001495725,0.009435962,0.0003171193,0.0001671432,0.000001159869,0.000005586764,0.0004168555,0.9891305,0.00002610797,0.0002983492,0.000004556985],"study_design_scores_gemma":[0.0003643861,0.0002007742,0.1464859,0.00008902983,0.0001019783,6.00659e-8,0.000003097068,0.0002952093,0.8515738,0.000002074103,0.000518849,0.0003648699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823079,0.001804232,0.01317295,0.00002698997,0.0008344731,0.0004458412,0.001355353,0.00004763658,0.000004668648],"genre_scores_gemma":[0.9974278,0.0001723849,0.001665909,0.00001211986,0.0005618003,0.00005983906,0.00001678934,0.00007856378,0.000004759067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1375567,"threshold_uncertainty_score":0.9997351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503413753029364,"score_gpt":0.2601749794701433,"score_spread":0.2451408419398497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}