{"id":"W2807387893","doi":"10.1126/science.aar5304","title":"Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Epitope; Circumsporozoite protein; Antibody; Affinity maturation; Biology; Antigen; Cell biology; Negative selection; Virology; Molecular biology; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206324,0.0002380811,0.0001420212,0.0001662119,0.00007794354,0.0001593702,0.0001694935,0.0002774794,0.002312537],"category_scores_gemma":[0.000227467,0.00008316539,0.00014799,0.00006182204,0.0001063924,0.0001048669,0.0002197999,0.0005394989,0.0003941621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083027,"about_ca_system_score_gemma":0.00008324625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003124531,"about_ca_topic_score_gemma":0.0003694771,"domain_scores_codex":[0.9998216,0.00004724083,0.00000922409,0.00003292292,0.00003836849,0.00005074266],"domain_scores_gemma":[0.999899,0.0000237613,0.00001895282,0.0000181233,0.00001610829,0.00002403509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006748033,0.00005833584,0.0001945303,0.00001165538,0.000004415538,0.00002663304,0.000008767472,0.000032829,0.9964876,0.00003917806,0.00004564171,0.003022866],"study_design_scores_gemma":[0.00004056484,0.001588071,0.007706459,0.00000336642,0.00002177814,0.0005923252,0.00001315992,0.0005125478,0.987839,0.00006305158,0.00161667,0.000003034102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949588,0.0006659079,0.00240341,0.00008843946,0.0000188437,0.00002931034,0.00004829929,0.000101579,0.001685255],"genre_scores_gemma":[0.9976904,0.0001491115,0.000988071,0.0000603623,0.00001067067,0.00000662304,0.00007163828,0.00001146747,0.001011685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002312537,"threshold_uncertainty_score":0.007736206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741798193750985,"score_gpt":0.2946599263621867,"score_spread":0.2772419444246768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}