{"id":"W2807416930","doi":"10.3389/fnins.2018.00402","title":"Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Monash University; Florida State University","keywords":"Neurite; Cell biology; Muscarinic acetylcholine receptor; Neuroscience; Pirenzepine; Cytoskeleton; Biology; Muscarinic acetylcholine receptor M1; Chemistry; Receptor; Biochemistry; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009734218,0.0002487712,0.0002379472,0.0001222109,0.0001246162,0.0001964531,0.0002061713,0.0001684997,0.0004291921],"category_scores_gemma":[0.00005051925,0.0001065499,0.0002478595,0.0001013366,0.0001200467,0.0001174786,0.0001482454,0.0003647444,0.000166961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003801236,"about_ca_system_score_gemma":0.0002412365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001407331,"about_ca_topic_score_gemma":0.003600819,"domain_scores_codex":[0.9999143,0.000008339815,0.00001183111,0.00001775154,0.00001976424,0.00002797745],"domain_scores_gemma":[0.9999588,0.000005616253,0.00001291125,0.000004718074,0.000006359649,0.00001172569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000384366,0.00001164944,0.00006576168,0.00001916814,0.000002346459,0.00001605355,0.000005828771,0.00003171801,0.9993723,0.00002403604,0.000008386862,0.0004043003],"study_design_scores_gemma":[0.00002104376,0.0003567244,0.00981266,0.000009894346,0.00001951901,0.0001132025,0.00003297581,0.0008707457,0.9876036,0.00003637024,0.001119727,0.000003528883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978721,0.000701104,0.000620811,0.00003330279,0.000006756367,0.000007604752,0.0001342704,0.00002434709,0.000599648],"genre_scores_gemma":[0.9944749,0.001512442,0.001495835,0.00004014632,0.000004685488,0.00003181225,0.000331918,0.00001161674,0.002096589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407331,"threshold_uncertainty_score":0.002798259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00923156476218876,"score_gpt":0.2362262693354421,"score_spread":0.2269947045732533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}