{"id":"W2807416930","doi":"10.3389/fnins.2018.00402","title":"Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Monash University; Florida State University","keywords":"Neurite; Cell biology; Muscarinic acetylcholine receptor; Neuroscience; Pirenzepine; Cytoskeleton; Biology; Muscarinic acetylcholine receptor M1; Chemistry; Receptor; Biochemistry; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434431,0.0001717299,0.0001698094,0.0001163453,0.0001277892,0.00006047574,0.0001725243,0.0001271871,0.000004647228],"category_scores_gemma":[0.0003016925,0.0001891448,0.00003212442,0.0003385749,0.0003273746,0.00002705975,0.0000991466,0.0001909609,7.152407e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001714751,"about_ca_system_score_gemma":0.00006296315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002433478,"about_ca_topic_score_gemma":0.0000233459,"domain_scores_codex":[0.9984982,0.0001315,0.0002252297,0.0006480394,0.0001368986,0.0003601568],"domain_scores_gemma":[0.9996014,0.00001134483,0.0001001087,0.0001540862,0.00004670701,0.00008634553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000763788,0.00004192011,0.003344522,0.000006973442,0.000001072966,0.000002223662,0.0001255087,0.0000196638,0.9918585,0.000006786861,0.0004885318,0.004027932],"study_design_scores_gemma":[0.000713752,0.0003122436,0.000925753,0.00003126574,0.000003557886,0.00001212889,0.0001192745,0.004420315,0.9918943,0.000006653935,0.001328566,0.0002321564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869042,0.0001245711,0.01058433,0.0001117663,0.001941231,0.0002155239,0.00002527307,0.00001567489,0.0000774092],"genre_scores_gemma":[0.9965305,0.0002243961,0.002397278,0.0005145087,0.0002057194,0.000006585726,0.00001455109,0.00002191269,0.00008454184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00962629,"threshold_uncertainty_score":0.7713102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00923156476218876,"score_gpt":0.2362262693354421,"score_spread":0.2269947045732533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}