{"id":"W2807500957","doi":"10.1038/s41421-018-0034-1","title":"Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry","year":2018,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Public Health Agency of Canada; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Public Health Agency","keywords":"Emetine; Zika virus; Virology; Ebola virus; Chloroquine; Viral replication; In vivo; In vitro; Pharmacology; Vero cell; Virus; Biology; Chemistry; Immunology; Malaria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921855,0.0002258399,0.0002840046,0.00007549718,0.0002557577,0.0001492587,0.00004801828,0.00008673376,0.00003044361],"category_scores_gemma":[0.0001646072,0.0002128383,0.00009480752,0.0001355908,0.0001535017,0.000450404,0.0001319256,0.0001716807,0.0000128886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004880221,"about_ca_system_score_gemma":0.00008620432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002782393,"about_ca_topic_score_gemma":0.00002836012,"domain_scores_codex":[0.9984852,0.00006608245,0.0003087794,0.0005914624,0.0002035228,0.0003449509],"domain_scores_gemma":[0.9991459,0.00004667413,0.0001376812,0.0004197326,0.00008786823,0.0001621943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002423361,0.0003157384,0.001700672,0.0001232132,0.00005814912,0.00002711024,0.0002608926,0.000002307444,0.9762373,0.01511686,0.0001249443,0.005790503],"study_design_scores_gemma":[0.005601991,0.0009335487,0.005692217,0.0004114479,0.0007134234,0.000142798,0.0006734848,0.001593316,0.9660263,0.01640118,0.00128296,0.0005273359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706705,0.001732276,0.02109356,0.0002465866,0.0001080531,0.0004663616,0.00002485238,0.00007897634,0.005578856],"genre_scores_gemma":[0.9965284,0.0002116704,0.001005782,0.001402754,0.0003613885,0.0000430327,0.00006602884,0.00003967126,0.0003412582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02585794,"threshold_uncertainty_score":0.8679295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007678050696275485,"score_gpt":0.2660924204222335,"score_spread":0.258414369725958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}