{"id":"W2807503561","doi":"10.1007/s40261-018-0660-2","title":"Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics","year":2018,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Pharmacokinetics; Tolerability; Medicine; Adverse effect; Placebo; Pharmacology; Morning; Evening; Dosing; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001686725,0.001709072,0.002907271,0.0006121767,0.0005510821,0.0006923322,0.000789243,0.001557759,0.002950585],"category_scores_gemma":[0.001292946,0.001120191,0.0008905478,0.0004695345,0.001258898,0.0009484035,0.0004503693,0.001755064,0.0007641879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005321091,"about_ca_system_score_gemma":0.001254488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166152,"about_ca_topic_score_gemma":0.002212476,"domain_scores_codex":[0.9992713,0.0003395648,0.00005660606,0.0001499171,0.00006399849,0.0001186313],"domain_scores_gemma":[0.9991618,0.0001493009,0.0001753958,0.00006854306,0.00007060268,0.0003742269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9230996,0.02735781,0.001303522,0.0003000622,0.000427359,0.0000886571,0.0001403527,0.0002951513,0.03074733,0.00004229612,0.000440002,0.01575775],"study_design_scores_gemma":[0.3736803,0.6157287,0.006654174,0.00001428292,0.0003671158,0.0000799252,0.00005470771,0.0003817903,0.00240033,0.00005402962,0.000554739,0.00002987071],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955689,0.001215249,0.0004578188,0.0001096761,0.00008786818,0.001659704,0.0003518312,0.00007700168,0.0004719873],"genre_scores_gemma":[0.9896954,0.001741762,0.001612378,0.0005741116,0.0002750179,0.003072829,0.0006712876,0.00002749317,0.00232976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002950585,"threshold_uncertainty_score":0.009870648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05515474089450226,"score_gpt":0.380198570377732,"score_spread":0.3250438294832297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}