{"id":"W2807503561","doi":"10.1007/s40261-018-0660-2","title":"Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics","year":2018,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Pharmacokinetics; Tolerability; Medicine; Adverse effect; Placebo; Pharmacology; Morning; Evening; Dosing; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001799736,0.0002367888,0.0004786488,0.0001008628,0.000133817,0.00003944118,0.0001220256,0.000187479,0.000003193089],"category_scores_gemma":[0.001066854,0.0002237492,0.00007049721,0.0002270361,0.0008839829,0.0000290695,0.0001677493,0.0002662725,0.000001244034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001229596,"about_ca_system_score_gemma":0.0001486195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007959134,"about_ca_topic_score_gemma":0.001431702,"domain_scores_codex":[0.9973838,0.0004175907,0.001155486,0.0005747785,0.0001886155,0.0002797537],"domain_scores_gemma":[0.9987511,0.0001577171,0.0003603843,0.0002608194,0.0001787168,0.0002912743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03464098,0.00108002,0.6922126,0.0001877861,0.0001828982,0.00000489716,0.004967809,0.00005038781,0.239911,0.00007568218,0.0005839019,0.02610209],"study_design_scores_gemma":[0.6228663,0.008762184,0.1292284,0.0004446977,0.0005230439,0.00003334345,0.004920708,0.0170853,0.2099736,0.0004773086,0.004318698,0.001366424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970641,0.0008414512,0.0003125818,0.0002589608,0.0003517468,0.001085191,0.00001594938,0.00001633417,0.00005376034],"genre_scores_gemma":[0.9960623,0.0004877142,0.00241918,0.0003632107,0.0004968351,0.00003181282,0.00006937391,0.00002777901,0.0000418306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5882253,"threshold_uncertainty_score":0.9124227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05515474089450226,"score_gpt":0.380198570377732,"score_spread":0.3250438294832297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}