{"id":"W2807527424","doi":"10.1038/s41598-018-20599-4","title":"Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Ottawa; McGill University; National Research Council Canada","funders":"","keywords":"Single-domain antibody; Monoclonal antibody; Clostridium difficile; Antibody; Clostridium difficile toxin A; Toxin; Mutant; Immunotoxin; Neutralization; Chemistry; Humanized antibody; Antitoxin; Recombinant DNA; Computational biology; Molecular biology; Biology; Biochemistry; Immunology; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003746157,0.0005114485,0.0002656537,0.0001892056,0.0001085603,0.000377966,0.0002798495,0.0002979692,0.0005809183],"category_scores_gemma":[0.0002790776,0.0001677754,0.0003079664,0.0001179809,0.0001671099,0.0001485793,0.0003211593,0.0004144451,0.0002371274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271377,"about_ca_system_score_gemma":0.0002503734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002079699,"about_ca_topic_score_gemma":0.0002524275,"domain_scores_codex":[0.9997321,0.00004393682,0.00002298776,0.00005276694,0.00009761876,0.00005059336],"domain_scores_gemma":[0.999886,0.00001598047,0.00004315715,0.00001269974,0.00002388187,0.00001824627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141043,0.0001006369,0.0003389232,0.00004769813,0.00001452482,0.00006184098,0.000009936191,0.005668751,0.9855076,0.0002305261,0.00008125293,0.007824238],"study_design_scores_gemma":[0.00003678091,0.001228753,0.0007028086,0.000004949528,0.00002504975,0.0001378151,0.000006536798,0.0131733,0.9818708,0.00005762434,0.002744851,0.00001074768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630983,0.0005467631,0.03382318,0.00010448,0.00003773047,0.0001389096,0.0001321695,0.0002593092,0.001859041],"genre_scores_gemma":[0.9710318,0.0003971537,0.02698341,0.00007013796,0.000008434567,0.00006025732,0.0001338386,0.00002769954,0.001287157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005809183,"threshold_uncertainty_score":0.001981199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752290401310477,"score_gpt":0.3272213489959674,"score_spread":0.2896984449828626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}