{"id":"W2807637103","doi":"10.1200/jco.2018.77.8084","title":"T Cells Genetically Modified to Express an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":791,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"NIH Clinical Center; National Cancer Institute; National Institutes of Health; Kite Pharma; AstraZeneca; Celgene; Gilead Sciences","keywords":"Medicine; Chimeric antigen receptor; Multiple myeloma; Minimal residual disease; Cytokine release syndrome; Antigen; Cyclophosphamide; Bone marrow; Fludarabine; Immunology; Regimen; Cancer research; Internal medicine; T cell; Oncology; Chemotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003521192,0.0002489644,0.001725144,0.00034952,0.0001082403,0.00002335334,0.0005121107,0.0007003599,0.001717882],"category_scores_gemma":[0.003317806,0.0001915046,0.0005177273,0.0004888546,0.0004915545,0.000162569,0.0001476259,0.001080789,0.00008814525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162619,"about_ca_system_score_gemma":0.001434802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004364363,"about_ca_topic_score_gemma":0.00001965836,"domain_scores_codex":[0.9940622,0.001096804,0.002996368,0.0004529663,0.0008832754,0.0005083808],"domain_scores_gemma":[0.9932472,0.001813929,0.001472527,0.0005508784,0.001683524,0.001231918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0102096,0.002464964,0.02329128,0.00003317707,0.0002544784,0.0001138603,0.0004073669,0.00003135172,0.9077067,0.000004732919,0.007632538,0.04784992],"study_design_scores_gemma":[0.009864193,0.03322637,0.2479816,0.0002179764,0.0002488729,0.0001167019,0.0002517743,0.001635585,0.6436263,0.00004104456,0.06248765,0.000301946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918557,0.0001394268,0.0008930776,0.003106453,0.001353845,0.0007209603,0.00001452482,0.00002301307,0.001893033],"genre_scores_gemma":[0.9564465,0.001375453,0.03792319,0.0009845967,0.002118967,0.000007085034,0.00001053587,0.00005780108,0.001075878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2640804,"threshold_uncertainty_score":0.9991947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1424856689320132,"score_gpt":0.4582241318970513,"score_spread":0.3157384629650381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}