{"id":"W2807637103","doi":"10.1200/jco.2018.77.8084","title":"T Cells Genetically Modified to Express an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":791,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"NIH Clinical Center; National Cancer Institute; National Institutes of Health; Kite Pharma; AstraZeneca; Celgene; Gilead Sciences","keywords":"Medicine; Chimeric antigen receptor; Multiple myeloma; Minimal residual disease; Cytokine release syndrome; Antigen; Cyclophosphamide; Bone marrow; Fludarabine; Immunology; Regimen; Cancer research; Internal medicine; T cell; Oncology; Chemotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102138,0.0003283453,0.0003961072,0.0001175353,0.0001674403,0.0001890978,0.000170384,0.000299945,0.001177161],"category_scores_gemma":[0.0002169144,0.0001200604,0.0002483866,0.00007995683,0.0003669375,0.0001415861,0.0001195059,0.000789164,0.000336298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163767,"about_ca_system_score_gemma":0.0001264386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002439303,"about_ca_topic_score_gemma":0.0003049152,"domain_scores_codex":[0.9998757,0.00002536248,0.000008835351,0.0000260424,0.00002536316,0.00003876053],"domain_scores_gemma":[0.9998819,0.00002201467,0.00003576119,0.0000155334,0.000006161464,0.00003864759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00727564,0.0022799,0.01230643,0.0002302,0.0001344399,0.001046183,0.000127741,0.001818435,0.9243938,0.0004513855,0.001232221,0.04870358],"study_design_scores_gemma":[0.01560407,0.1474252,0.08975571,0.00008322821,0.0006788663,0.01809109,0.000182641,0.008536153,0.6895587,0.0006784301,0.02933825,0.00006764154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981799,0.0006519293,0.0004833538,0.00007275089,0.00002656379,0.00005007267,0.00004901912,0.00005368644,0.0004327398],"genre_scores_gemma":[0.9986163,0.0002397825,0.0003644942,0.0000759878,0.000020769,0.00003616044,0.0001247108,0.000007199209,0.0005146086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177161,"threshold_uncertainty_score":0.003938019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1424856689320132,"score_gpt":0.4582241318970513,"score_spread":0.3157384629650381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}